The transplanted kidney as a source of cytomegalovirus infection - PubMed (original) (raw)
The transplanted kidney as a source of cytomegalovirus infection
M Ho et al. N Engl J Med. 1975.
Abstract
To determine the incidence of cytomegalovirus infection in renal-transplant recipients we followed 32 prospectively for six months after operation. As judged by serologic change and virus isolation the infection rate for the entire group was 66 per cent (21 of 32 patients) - 59 per cent (13 of 22) for seronegative patients and 80 per cent (eight of 10) for seropositive patients. Of 10 seronegative patients who received kidneys from seronegative donors, only three became infected. However, of 12 seronegative patients who received kidneys from seropositive donors, 10 became infected. Thus, there was a significant correlation between development of infection and seropositivity of the donor (P = 0.03), particularly when the recipient was seronegative (P = 0.02). Five possible and four definite recognizable clinical illnesses were associated with cytomegalovirus infection; all except two were in initially seronegative subjects who received kidneys from seropositive donors. Primary infection and disease in nonimmune recipients may be caused by cytomegalovirus transmitted by the kidneys of latently infected seropositive donors.
Similar articles
- [incidence of cytomegalovirus infections following transplantation of kidneys from seropositive and seronegative donors].
Kaden J, Adamczyk G, Eichler C, Strobelt V, Groth J, Janisch W, May G. Kaden J, et al. Z Urol Nephrol. 1985 May;78(5):267-71. Z Urol Nephrol. 1985. PMID: 2994321 German. - Primary and secondary cytomegalovirus infection.
Suwansirikul S, Rao N, Dowling JN, Ho M. Suwansirikul S, et al. Arch Intern Med. 1977 Aug;137(8):1026-9. Arch Intern Med. 1977. PMID: 195547 - The effects of viral infections on renal transplants and their recipients.
Warrell MJ, Chinn I, Morris PJ, Tobin JO. Warrell MJ, et al. Q J Med. 1980 Spring;49(194):219-31. Q J Med. 1980. PMID: 6254109 - [HLA antigens are associated in seronegativity to cytomegalovirus(CMV)].
Machida S, Takahashi T, Nomoto K, Murata S. Machida S, et al. Nihon Rinsho. 1998 Jan;56(1):129-33. Nihon Rinsho. 1998. PMID: 9465677 Review. Japanese. - Reducing the risk for transfusion-transmitted cytomegalovirus infection.
Sayers MH, Anderson KC, Goodnough LT, Kurtz SR, Lane TA, Pisciotto P, Silberstein LE. Sayers MH, et al. Ann Intern Med. 1992 Jan 1;116(1):55-62. doi: 10.7326/0003-4819-116-1-55. Ann Intern Med. 1992. PMID: 1309201 Review.
Cited by
- Memory CD8 T Cells Protect against Cytomegalovirus Disease by Formation of Nodular Inflammatory Foci Preventing Intra-Tissue Virus Spread.
Holtappels R, Podlech J, Freitag K, Lemmermann NA, Reddehase MJ. Holtappels R, et al. Viruses. 2022 May 25;14(6):1145. doi: 10.3390/v14061145. Viruses. 2022. PMID: 35746617 Free PMC article. - Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells.
Hamdan S, Reddehase MJ, Holtappels R. Hamdan S, et al. Med Microbiol Immunol. 2023 Apr;212(2):153-163. doi: 10.1007/s00430-022-00733-w. Epub 2022 Apr 1. Med Microbiol Immunol. 2023. PMID: 35364731 Free PMC article. Review. - The impact of donor viral replication at transplant on recipient infections posttransplant: a prospective study.
Verghese PS, Schmeling DO, Knight JA, Matas AJ, Balfour HH Jr. Verghese PS, et al. Transplantation. 2015 Mar;99(3):602-8. doi: 10.1097/TP.0000000000000354. Transplantation. 2015. PMID: 25148381 Free PMC article. - Clinical utility of viral load in management of cytomegalovirus infection after solid organ transplantation.
Razonable RR, Hayden RT. Razonable RR, et al. Clin Microbiol Rev. 2013 Oct;26(4):703-27. doi: 10.1128/CMR.00015-13. Clin Microbiol Rev. 2013. PMID: 24092851 Free PMC article. Review. - Shedding light on the elusive role of endothelial cells in cytomegalovirus dissemination.
Sacher T, Andrassy J, Kalnins A, Dölken L, Jordan S, Podlech J, Ruzsics Z, Jauch KW, Reddehase MJ, Koszinowski UH. Sacher T, et al. PLoS Pathog. 2011 Nov;7(11):e1002366. doi: 10.1371/journal.ppat.1002366. Epub 2011 Nov 17. PLoS Pathog. 2011. PMID: 22114552 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials