Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition - PubMed (original) (raw)

Multicenter Study

. 2006 Dec;15(12):2398-407.

doi: 10.1158/1055-9965.EPI-06-0595.

Teresa Norat, Karen Steindorf, Marie-Christine Boutron-Ruault, Tobias Pischon, Mathieu Mazuir, Françoise Clavel-Chapelon, Jakob Linseisen, Heiner Boeing, Manuela Bergman, Nina Fons Johnsen, Anne Tjønneland, Kim Overvad, Michelle Mendez, J Ramón Quirós, Carmen Martinez, Miren Dorronsoro, Carmen Navarro, Aurelio Barricarte Gurrea, Sheila Bingham, Kay-Tee Khaw, Naomi Allen, Tim Key, Antonia Trichopoulou, Dimitrios Trichopoulos, Natassa Orfanou, Vittorio Krogh, Domenico Palli, Rosario Tumino, Salvatore Panico, Paolo Vineis, H Bas Bueno-de-Mesquita, Petra H M Peeters, Evelyn Monninkhof, Göran Berglund, Jonas Manjer, Pietro Ferrari, Nadia Slimani, Rudolf Kaaks, Elio Riboli

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Multicenter Study

Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition

Christine Friedenreich et al. Cancer Epidemiol Biomarkers Prev. 2006 Dec.

Abstract

We investigated several aspects of the role of physical activity in colon and rectal cancer etiology that remain unclear in the European Prospective Investigation into Nutrition and Cancer. This cohort of 413,044 men and women had 1,094 cases of colon and 599 cases of rectal cancer diagnosed during an average of 6.4 years of follow-up. We analyzed baseline data on occupational, household, and recreational activity to examine associations by type of activity, tumor subsite, body mass index (BMI), and energy intake. The multivariate hazard ratio for colon cancer was 0.78 [95% confidence interval (95% CI), 0.59-1.03] among the most active participants when compared with the inactive, with evidence of a dose-response effect (P(trend) = 0.04). For right-sided colon tumors, the risk was 0.65 (95% CI, 0.43-1.00) in the highest quartile of activity with evidence of a linear trend (P(trend) = 0.004). Active participants with a BMI under 25 had a risk of 0.63 (95% CI, 0.39-1.01) for colon cancer compared with the inactive. Finally, an interaction between BMI and activity (P(interaction) = 0.03) was observed for right-sided colon cancers; among moderately active and active participants with a BMI under 25, a risk of 0.38 (95% CI, 0.21-0.68) was found as compared with inactive participants with BMI >30. No comparable decreased risks were observed for rectal cancer for any type of physical activity for any subgroup analyses or interactions considered. We found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.

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