Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region - PubMed (original) (raw)
. 2007 Jan;134(2):417-26.
doi: 10.1242/dev.02726. Epub 2006 Dec 13.
Affiliations
- PMID: 17166925
- DOI: 10.1242/dev.02726
Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region
Shau-Ping Lin et al. Development. 2007 Jan.
Abstract
Genomic imprinting is an epigenetic mechanism controlling parental-origin-specific gene expression. Perturbing the parental origin of the distal portion of mouse chromosome 12 causes alterations in the dosage of imprinted genes resulting in embryonic lethality and developmental abnormalities of both embryo and placenta. A 1 Mb imprinted domain identified on distal chromosome 12 contains three paternally expressed protein-coding genes and multiple non-coding RNA genes, including snoRNAs and microRNAs, expressed from the maternally inherited chromosome. An intergenic, parental-origin-specific differentially methylated region, the IG-DMR, which is unmethylated on the maternally inherited chromosome, is necessary for the repression of the paternally expressed protein-coding genes and for activation of the maternally expressed non-coding RNAs: its absence causes the maternal chromosome to behave like the paternally inherited one. Here, we characterise the developmental consequences of this epigenotype switch and compare these with phenotypes associated with paternal uniparental disomy of mouse chromosome 12. The results show that the embryonic defects described for uniparental disomy embryos can be attributed to this one cluster of imprinted genes on distal chromosome 12 and that these defects alone, and not the mutant placenta, can cause prenatal lethality. In the placenta, the absence of the IG-DMR has no phenotypic consequence. Loss of repression of the protein-coding genes occurs but the non-coding RNAs are not repressed on the maternally inherited chromosome. This indicates that the mechanism of action of the IG-DMR is different in the embryo and the placenta and suggests that the epigenetic control of imprinting differs in these two lineages.
Similar articles
- A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development.
Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H, Takada S. Saito T, et al. Hum Mol Genet. 2018 Sep 15;27(18):3283-3292. doi: 10.1093/hmg/ddy235. Hum Mol Genet. 2018. PMID: 29931170 - At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.
Hagan JP, O'Neill BL, Stewart CL, Kozlov SV, Croce CM. Hagan JP, et al. PLoS One. 2009;4(2):e4352. doi: 10.1371/journal.pone.0004352. Epub 2009 Feb 5. PLoS One. 2009. PMID: 19194500 Free PMC article. - Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12.
Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J, Ferguson-Smith AC. Lin SP, et al. Nat Genet. 2003 Sep;35(1):97-102. doi: 10.1038/ng1233. Epub 2003 Aug 24. Nat Genet. 2003. PMID: 12937418 - [Review on the genomic imprinting at the mammalian DLK1-DIO3 cluster.].
Zhao LX, Zhao GP, Zhou HM. Zhao LX, et al. Yi Chuan. 2010 Aug;32(8):769-78. doi: 10.3724/sp.j.1005.2010.00769. Yi Chuan. 2010. PMID: 20709673 Review. Chinese. - Genomic imprinting at the mammalian Dlk1-Dio3 domain.
da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC. da Rocha ST, et al. Trends Genet. 2008 Jun;24(6):306-16. doi: 10.1016/j.tig.2008.03.011. Trends Genet. 2008. PMID: 18471925 Review.
Cited by
- Association of DNA Methylation with Infant Birth Weight in Women with Gestational Diabetes.
Saucedo R, Ferreira-Hermosillo A, Robledo-Clemente M, Díaz-Velázquez MF, Valencia-Ortega J. Saucedo R, et al. Metabolites. 2024 Jun 27;14(7):361. doi: 10.3390/metabo14070361. Metabolites. 2024. PMID: 39057684 Free PMC article. Review. - Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature.
Zhang X, He H, Yu H, Teng X, Wang Z, Li C, Li J, Yang H, Shen J, Wu T, Zhang F, Zhang Y, Wu Q. Zhang X, et al. Commun Biol. 2024 Mar 23;7(1):363. doi: 10.1038/s42003-024-06038-3. Commun Biol. 2024. PMID: 38521877 Free PMC article. - Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain.
Weinberg-Shukron A, Youngson NA, Ferguson-Smith AC, Edwards CA. Weinberg-Shukron A, et al. Front Cell Dev Biol. 2023 Dec 12;11:1328806. doi: 10.3389/fcell.2023.1328806. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38155837 Free PMC article. Review. - Altered expression of long noncoding RNA MEG3 in the offspring of gestational diabetes mellitus induces impaired glucose tolerance in adulthood.
Yang MM, Wei J, Xu LL, Yan YS, Chen Y, Lv M, Jiang Y, Luo Q. Yang MM, et al. Acta Diabetol. 2024 Jan;61(1):79-90. doi: 10.1007/s00592-023-02169-x. Epub 2023 Sep 9. Acta Diabetol. 2024. PMID: 37688646 - _Meg8_-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice.
Zhang L, Han Z, He H, Zhang X, Zhang M, Li B, Wu Q. Zhang L, et al. Genes (Basel). 2023 Jun 14;14(6):1264. doi: 10.3390/genes14061264. Genes (Basel). 2023. PMID: 37372444 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous