No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes - PubMed (original) (raw)
. 2007 Feb 21;413(3):202-5.
doi: 10.1016/j.neulet.2006.11.044. Epub 2006 Dec 15.
Affiliations
- PMID: 17174475
- DOI: 10.1016/j.neulet.2006.11.044
No association between Parkinson's disease and three polymorphisms in the eNOS, nNOS, and iNOS genes
Cecilia Huerta et al. Neurosci Lett. 2007.
Abstract
Nitric oxide synthases (NOS) and mitochondrial DNA-polymorphisms have been associated with the risk of developing Parkinson's disease (PD). In this report, we genotyped 450 PD-patients and 200 controls for three polymorphisms in the endothelial, inducible and neuronal NOS-genes, and for the T4336C and A10398G mitochondrial DNA-polymorphisms. None of the eNOS (intron 4 VNTR), iNOS (exon 22 A/G), or nNOS (exon 29T/C) were significantly associated with PD. Mitochondrial 4336C increased the PD-risk among women (OR=6.13), while the 10398G had a protective effect (OR=0.52). We did not find significantly interactions between the NOS and mitochondrial polymorphisms in the risk for PD in our population.
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