Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk - PubMed (original) (raw)
doi: 10.1207/s15327914nc5601_5.
James I Taylor, Philip B Grace, Angela A Mulligan, Ailsa A Welch, Serena Scollen, Alison M Dunning, Robert N Luben, Kay-Tee Khaw, Nick E Day, Nick J Wareham, Sheila A Bingham
Affiliations
- PMID: 17176215
- DOI: 10.1207/s15327914nc5601_5
Phytoestrogen exposure, polymorphisms in COMT, CYP19, ESR1, and SHBG genes, and their associations with prostate cancer risk
Yen-Ling Low et al. Nutr Cancer. 2006.
Abstract
Prospective phytoestrogen exposure was assessed using both biomarkers and estimates of intake in 89 British men recruited into the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition study, men who subsequently developed prostate cancer. Results were compared with those from 178 healthy men matched by age and date of recruitment. Levels of seven phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin, equol, enterodiol, and enterolactone) were measured in spot urine and serum samples. Five single-nucleotide polymorphisms in COMT, CYP19, ESR1, and SHBG genes were genotyped. Urinary levels of all phytoestrogens correlated strongly with serum levels. Correlation coefficients ranged from 0.63 (glycitein) to 0.88 (daidzein) (P < 0.001). Urinary and serum levels correlated significantly with isoflavone intake assessed from food diaries (R = 0.15-0.20; P < 0.05) but not with that from a food-frequency questionnaire. Odds ratios for phytoestrogen exposure, as assessed using the four methods, were not significantly associated with prostate cancer risk (P = 0.15-0.94). Men with the CC genotype for the ESRI PvuII polymorphism had significantly higher risk for prostate cancer compared with men with the TT genotype [adjusted odds ratio = 4.65 (1.60-13.49); P = 0.005]. Our results utilizing a combined prospective exposure provide no evidence that phytoestrogens alter prostate cancer risk in British men, whereas the C allele for the PvuII polymorphism may be associated with increased risk.
Similar articles
- Polymorphisms in the CYP19 gene may affect the positive correlations between serum and urine phytoestrogen metabolites and plasma androgen concentrations in men.
Low YL, Taylor JI, Grace PB, Dowsett M, Folkerd E, Doody D, Dunning AM, Scollen S, Mulligan AA, Welch AA, Luben RN, Khaw KT, Day NE, Wareham NJ, Bingham SA. Low YL, et al. J Nutr. 2005 Nov;135(11):2680-6. doi: 10.1093/jn/135.11.2680. J Nutr. 2005. PMID: 16251630 - Phytoestrogen exposure correlation with plasma estradiol in postmenopausal women in European Prospective Investigation of Cancer and Nutrition-Norfolk may involve diet-gene interactions.
Low YL, Taylor JI, Grace PB, Dowsett M, Scollen S, Dunning AM, Mulligan AA, Welch AA, Luben RN, Khaw KT, Day NE, Wareham NJ, Bingham SA. Low YL, et al. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):213-20. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 15668497 - Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European prospective investigation of cancer and nutrition-norfolk.
Grace PB, Taylor JI, Low YL, Luben RN, Mulligan AA, Botting NP, Dowsett M, Welch AA, Khaw KT, Wareham NJ, Day NE, Bingham SA. Grace PB, et al. Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):698-708. Cancer Epidemiol Biomarkers Prev. 2004. PMID: 15159299 - Is phytoestrogen intake associated with decreased risk of prostate cancer? A systematic review of epidemiological studies based on 17,546 cases.
Zhang M, Wang K, Chen L, Yin B, Song Y. Zhang M, et al. Andrology. 2016 Jul;4(4):745-56. doi: 10.1111/andr.12196. Epub 2016 Jun 3. Andrology. 2016. PMID: 27260185 Review. - ESR1 Gene Polymorphisms and Prostate Cancer Risk: A HuGE Review and Meta-Analysis.
Wang YM, Liu ZW, Guo JB, Wang XF, Zhao XX, Zheng X. Wang YM, et al. PLoS One. 2013 Jun 21;8(6):e66999. doi: 10.1371/journal.pone.0066999. Print 2013. PLoS One. 2013. PMID: 23805288 Free PMC article. Review.
Cited by
- Association between polyphenol subclasses and prostate cancer: a systematic review and meta-analysis of observational studies.
Huang Y, Wang W, Jin J. Huang Y, et al. Front Nutr. 2024 Jul 31;11:1428911. doi: 10.3389/fnut.2024.1428911. eCollection 2024. Front Nutr. 2024. PMID: 39144286 Free PMC article. - Genetic Variation in Steroid and Xenobiotic Metabolizing Pathways and Enterolactone Excretion Before and After Flaxseed Intervention in African American and European American Women.
Chang H, Yao S, Tritchler D, Hullar MA, Lampe JW, Thompson LU, McCann SE. Chang H, et al. Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):265-274. doi: 10.1158/1055-9965.EPI-18-0826. Cancer Epidemiol Biomarkers Prev. 2019. PMID: 30709839 Free PMC article. Clinical Trial. - ESR1 PvuII (rs2234693 T>C) polymorphism and cancer susceptibility: Evidence from 80 studies.
Liu X, Huang J, Lin H, Xiong L, Ma Y, Lao H. Liu X, et al. J Cancer. 2018 Jul 30;9(16):2963-2972. doi: 10.7150/jca.25638. eCollection 2018. J Cancer. 2018. PMID: 30123365 Free PMC article. Review. - Soy Consumption and the Risk of Prostate Cancer: An Updated Systematic Review and Meta-Analysis.
Applegate CC, Rowles JL, Ranard KM, Jeon S, Erdman JW. Applegate CC, et al. Nutrients. 2018 Jan 4;10(1):40. doi: 10.3390/nu10010040. Nutrients. 2018. PMID: 29300347 Free PMC article. Review. - Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis.
Li G, Yang M, Li X, Deng S. Li G, et al. Oncotarget. 2017 Sep 21;8(60):102310-102320. doi: 10.18632/oncotarget.21117. eCollection 2017 Nov 24. Oncotarget. 2017. PMID: 29254246 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous