Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation - PubMed (original) (raw)

doi: 10.1038/ncb1530. Epub 2006 Dec 24.

Kate D Sutherland, Holly Barker, Richard Thomas, Mark Shackleton, Natasha C Forrest, Lynne Hartley, Lorraine Robb, Frank G Grosveld, Jacqueline van der Wees, Geoffrey J Lindeman, Jane E Visvader

Affiliations

• PMID: 17187062
• DOI: 10.1038/ncb1530

Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation

Marie-Liesse Asselin-Labat et al. Nat Cell Biol. 2007 Feb.

Abstract

The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer. To gain insight into the role of Gata-3 in breast epithelial development and oncogenesis, we have explored its normal function within the mammary gland by conditionally deleting Gata-3 at different stages of development. We report that Gata-3 has essential roles in the morphogenesis of the mammary gland in both the embryo and adult. Through the discovery of a novel marker (beta3-integrin) of luminal progenitor cells and their purification, we demonstrate that Gata-3 deficiency leads to an expansion of luminal progenitors and a concomitant block in differentiation. Remarkably, introduction of Gata-3 into a stem cell-enriched population induced maturation along the alveolar luminal lineage. These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation.

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Comment in

• Luminal cells GATA have it.
  Tlsty TD. Tlsty TD. Nat Cell Biol. 2007 Feb;9(2):135-6. doi: 10.1038/ncb0207-135. Nat Cell Biol. 2007. PMID: 17268476 No abstract available.

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