Selective inhibitors of death in mutant huntingtin cells - PubMed (original) (raw)

doi: 10.1038/nchembio852. Epub 2006 Dec 31.

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• PMID: 17195849
• DOI: 10.1038/nchembio852

Selective inhibitors of death in mutant huntingtin cells

Hemant Varma et al. Nat Chem Biol. 2007 Feb.

Abstract

Huntington disease (HD) is an inherited neurodegenerative disorder with unclear pathophysiology. We developed a high-throughput assay in a neuronal cell culture model of HD, screened 43,685 compounds and identified 29 novel selective inhibitors of cell death in mutant huntingtin-expressing cells. Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD.

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