Endoplasmic reticulum stress: a new pathway to induce autophagy - PubMed (original) (raw)

. 2007 Mar-Apr;3(2):160-2.

doi: 10.4161/auto.3653. Epub 2007 Mar 4.

Affiliations

• PMID: 17204854
• DOI: 10.4161/auto.3653

Endoplasmic reticulum stress: a new pathway to induce autophagy

Tomohiro Yorimitsu et al. Autophagy. 2007 Mar-Apr.

Abstract

Autophagy is a response to the stress of nutrient limitation in yeast, whereby cytosolic long-lived proteins and organelles are nonselectively degraded, and the resulting macromolecules are recycled to allow new protein synthesis that is essential for survival. We recently revealed that endoplasmic reticulum (ER) stress induces autophagy. When misfolded proteins accumulate in the ER the resulting stress activates the unfolded protein response (UPR) to induce the expression of chaperones and proteins involved in the recovery process. Under conditions of ER stress, the preautophagosomal structure is assembled, and transport of autophagosomes to the vacuole is stimulated in an Atg protein-dependent manner. Interestingly, Atg1 has high kinase activity during ER stress-induced autophagy similar to the situation in starvation-induced autophagy.

PubMed Disclaimer

Similar articles

• Endoplasmic reticulum stress triggers autophagy.
  Yorimitsu T, Nair U, Yang Z, Klionsky DJ. Yorimitsu T, et al. J Biol Chem. 2006 Oct 6;281(40):30299-304. doi: 10.1074/jbc.M607007200. Epub 2006 Aug 10. J Biol Chem. 2006. PMID: 16901900 Free PMC article.
• Activation of autophagy by unfolded proteins during endoplasmic reticulum stress.
  Yang X, Srivastava R, Howell SH, Bassham DC. Yang X, et al. Plant J. 2016 Jan;85(1):83-95. doi: 10.1111/tpj.13091. Plant J. 2016. PMID: 26616142
• A Role for Macro-ER-Phagy in ER Quality Control.
  Lipatova Z, Segev N. Lipatova Z, et al. PLoS Genet. 2015 Jul 16;11(7):e1005390. doi: 10.1371/journal.pgen.1005390. eCollection 2015 Jul. PLoS Genet. 2015. PMID: 26181331 Free PMC article.
• Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury.
  Yan M, Shu S, Guo C, Tang C, Dong Z. Yan M, et al. Ann Med. 2018 Aug;50(5):381-390. doi: 10.1080/07853890.2018.1489142. Epub 2018 Jul 11. Ann Med. 2018. PMID: 29895209 Free PMC article. Review.
• Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.
  Høyer-Hansen M, Jäättelä M. Høyer-Hansen M, et al. Cell Death Differ. 2007 Sep;14(9):1576-82. doi: 10.1038/sj.cdd.4402200. Epub 2007 Jul 6. Cell Death Differ. 2007. PMID: 17612585 Review.

Cited by

• A View into Seed Autophagy: From Development to Environmental Responses.
  Iglesias-Fernández R, Vicente-Carbajosa J. Iglesias-Fernández R, et al. Plants (Basel). 2022 Nov 26;11(23):3247. doi: 10.3390/plants11233247. Plants (Basel). 2022. PMID: 36501287 Free PMC article.
• Dengue 2 infection of HepG2 liver cells results in endoplasmic reticulum stress and induction of multiple pathways of cell death.
  Thepparit C, Khakpoor A, Khongwichit S, Wikan N, Fongsaran C, Chingsuwanrote P, Panraksa P, Smith DR. Thepparit C, et al. BMC Res Notes. 2013 Sep 14;6:372. doi: 10.1186/1756-0500-6-372. BMC Res Notes. 2013. PMID: 24034452 Free PMC article.
• Autophagy and the effects of its inhibition on varicella-zoster virus glycoprotein biosynthesis and infectivity.
  Buckingham EM, Carpenter JE, Jackson W, Grose C. Buckingham EM, et al. J Virol. 2014 Jan;88(2):890-902. doi: 10.1128/JVI.02646-13. Epub 2013 Nov 6. J Virol. 2014. PMID: 24198400 Free PMC article.
• Autophagy facilitates antibody-enhanced dengue virus infection in human pre-basophil/mast cells.
  Fang YT, Wan SW, Lu YT, Yao JH, Lin CF, Hsu LJ, Brown MG, Marshall JS, Anderson R, Lin YS. Fang YT, et al. PLoS One. 2014 Oct 16;9(10):e110655. doi: 10.1371/journal.pone.0110655. eCollection 2014. PLoS One. 2014. PMID: 25329914 Free PMC article.
• NF-_κ_B pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells.
  Zhu X, Huang L, Gong J, Shi C, Wang Z, Ye B, Xuan A, He X, Long D, Zhu X, Ma N, Leng S. Zhu X, et al. Cell Death Discov. 2017 Sep 11;3:17059. doi: 10.1038/cddiscovery.2017.59. eCollection 2017. Cell Death Discov. 2017. PMID: 28904818 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Taylor & Francis

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Saccharomyces Genome Database