Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease - PubMed (original) (raw)
Review
. 2007 Apr;44(10):2497-506.
doi: 10.1016/j.molimm.2006.11.025. Epub 2007 Jan 17.
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- PMID: 17208301
- DOI: 10.1016/j.molimm.2006.11.025
Review
Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
Lynda A O'Sullivan et al. Mol Immunol. 2007 Apr.
Abstract
The complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.
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