Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition - PubMed (original) (raw)
. 1991 Dec 12;354(6353):453-9.
doi: 10.1038/354453a0.
Affiliations
- PMID: 1721107
- DOI: 10.1038/354453a0
Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
R E Phillips et al. Nature. 1991.
Abstract
In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope sequences in the lymphocytes of these patients. Some of these viral variants are not recognized by autologous T cells. Accumulation of such mutations in T-cell antigenic targets would provide a mechanism for immune escape.
Comment in
- HIV. Games that viruses play.
Zinkernagel RM, Hengartner H. Zinkernagel RM, et al. Nature. 1991 Dec 12;354(6353):433-4. doi: 10.1038/354433a0. Nature. 1991. PMID: 1721106 No abstract available.
Similar articles
- Molecular and functional analysis of a conserved CTL epitope in HIV-1 p24 recognized from a long-term nonprogressor: constraints on immune escape associated with targeting a sequence essential for viral replication.
Wagner R, Leschonsky B, Harrer E, Paulus C, Weber C, Walker BD, Buchbinder S, Wolf H, Kalden JR, Harrer T. Wagner R, et al. J Immunol. 1999 Mar 15;162(6):3727-34. J Immunol. 1999. PMID: 10092836 - Sequence constraints and recognition by CTL of an HLA-B27-restricted HIV-1 gag epitope.
Nietfield W, Bauer M, Fevrier M, Maier R, Holzwarth B, Frank R, Maier B, Riviere Y, Meyerhans A. Nietfield W, et al. J Immunol. 1995 Mar 1;154(5):2189-97. J Immunol. 1995. PMID: 7868892 - Human immunodeficiency virus variants that escape cytotoxic T-cell recognition.
Rowland-Jones SL, Phillips RE, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CR, Rizza CR, et al. Rowland-Jones SL, et al. AIDS Res Hum Retroviruses. 1992 Aug;8(8):1353-4. doi: 10.1089/aid.1992.8.1353. AIDS Res Hum Retroviruses. 1992. PMID: 1466955 No abstract available. - Cytotoxic T lymphocytes and viral evolution in primary HIV-1 infection.
Price DA, O'callaghan CA, Whelan JA, Easterbrook PJ, Phillips RE. Price DA, et al. Clin Sci (Lond). 1999 Dec;97(6):707-18. Clin Sci (Lond). 1999. PMID: 10585898 Review. - Defying death--HIV mutation to evade cytotoxic T lymphocytes.
Lieberman J. Lieberman J. N Engl J Med. 2002 Oct 10;347(15):1203-4. doi: 10.1056/NEJMcibr022067. N Engl J Med. 2002. PMID: 12374884 Review. No abstract available.
Cited by
- Energy demanding RNA and protein metabolism drive dysfunctionality of HIV-specific T cell changes during chronic HIV infection.
van Pul L, Stunnenberg M, Kroeze S, van Dort KA, Boeser-Nunnink BDM, Harskamp AM, Geijtenbeek TBH, Kootstra NA. van Pul L, et al. PLoS One. 2024 Oct 2;19(10):e0298472. doi: 10.1371/journal.pone.0298472. eCollection 2024. PLoS One. 2024. PMID: 39356699 Free PMC article. - HIV Persistence, Latency, and Cure Approaches: Where Are We Now?
Chou TC, Maggirwar NS, Marsden MD. Chou TC, et al. Viruses. 2024 Jul 19;16(7):1163. doi: 10.3390/v16071163. Viruses. 2024. PMID: 39066325 Free PMC article. Review. - Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.
Nelson GW, van Duijn J, Yuki Y, Pau MG, Tomaka F, Lavreys L, DeRosa SC, McElrath MJ, Kirk GD, Michael NL, Haas DW, Deeks SG, Wolinsky S, Walker B, Barouch DH, Stieh D, Carrington M. Nelson GW, et al. J Virol. 2024 Aug 20;98(8):e0028124. doi: 10.1128/jvi.00281-24. Epub 2024 Jul 24. J Virol. 2024. PMID: 39046263 Clinical Trial. - Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation.
Xu ZM, Gnouamozi GE, Rüeger S, Shea PR, Buti M, Chan HL, Marcellin P, Lawless D, Naret O, Zeller M, Schneuing A, Scheck A, Junier T, Moradpour D, Podlaha O, Suri V, Gaggar A, Subramanian M, Correia B, Gfeller D, Urban S, Fellay J. Xu ZM, et al. Am J Hum Genet. 2024 Jun 6;111(6):1018-1034. doi: 10.1016/j.ajhg.2024.04.013. Epub 2024 May 14. Am J Hum Genet. 2024. PMID: 38749427 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical