Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3 - PubMed (original) (raw)
doi: 10.1038/ni1437. Epub 2007 Jan 14.
Affiliations
- PMID: 17220892
- DOI: 10.1038/ni1437
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Luke M Williams et al. Nat Immunol. 2007 Mar.
Abstract
The transcription factor Foxp3 is required for the development of regulatory T cells (T(reg) cell). Here we report that induced ablation of a loxP-flanked Foxp3 allele in mature T(reg) cells resulted in the loss of their suppressive function in vivo and acquisition of the ability to produce interleukin 2 and T helper type 1 cytokines. Furthermore, after adoptive transfer in the absence of functional T(reg) cells into lymphopenic hosts, T(reg) cells with deletion of Foxp3 proliferated and were predominant among tissue-infiltrating T cells. In agreement with those results, we found deregulation of Foxp3 target gene expression after Foxp3 deletion. Thus, continued Foxp3 expression in mature T(reg) cells is needed to maintain the transcriptional and functional program established during T(reg) cell development.
Similar articles
- Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10.
Maynard CL, Harrington LE, Janowski KM, Oliver JR, Zindl CL, Rudensky AY, Weaver CT. Maynard CL, et al. Nat Immunol. 2007 Sep;8(9):931-41. doi: 10.1038/ni1504. Epub 2007 Aug 12. Nat Immunol. 2007. PMID: 17694059 - Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.
Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C. Hill JA, et al. Immunity. 2007 Nov;27(5):786-800. doi: 10.1016/j.immuni.2007.09.010. Immunity. 2007. PMID: 18024188 - TGF-beta1 modulates Foxp3 expression and regulatory activity in distinct CD4+ T cell subsets.
Pyzik M, Piccirillo CA. Pyzik M, et al. J Leukoc Biol. 2007 Aug;82(2):335-46. doi: 10.1189/jlb.1006644. Epub 2007 May 2. J Leukoc Biol. 2007. PMID: 17475784 - Plasticity of T(reg) cells: is reprogramming of T(reg) cells possible in the presence of FOXP3?
Beyer M, Schultze JL. Beyer M, et al. Int Immunopharmacol. 2011 May;11(5):555-60. doi: 10.1016/j.intimp.2010.11.024. Epub 2010 Nov 27. Int Immunopharmacol. 2011. PMID: 21115121 Review. - The role of the transcription factor Foxp3 in the development of regulatory T cells.
Kim JM, Rudensky A. Kim JM, et al. Immunol Rev. 2006 Aug;212:86-98. doi: 10.1111/j.0105-2896.2006.00426.x. Immunol Rev. 2006. PMID: 16903908 Review.
Cited by
- Tregs in transplantation tolerance: role and therapeutic potential.
Cassano A, Chong AS, Alegre ML. Cassano A, et al. Front Transplant. 2023 Aug 30;2:1217065. doi: 10.3389/frtra.2023.1217065. eCollection 2023. Front Transplant. 2023. PMID: 38993904 Free PMC article. Review. - FGL1 and FGL2: emerging regulators of liver health and disease.
Chen J, Wu L, Li Y. Chen J, et al. Biomark Res. 2024 May 31;12(1):53. doi: 10.1186/s40364-024-00601-0. Biomark Res. 2024. PMID: 38816776 Free PMC article. Review. - The inhibitory effect of adenosine on tumor adaptive immunity and intervention strategies.
Wang L, Zhang J, Zhang W, Zheng M, Guo H, Pan X, Li W, Yang B, Ding L. Wang L, et al. Acta Pharm Sin B. 2024 May;14(5):1951-1964. doi: 10.1016/j.apsb.2023.12.004. Epub 2023 Dec 16. Acta Pharm Sin B. 2024. PMID: 38799637 Free PMC article. Review. - Increased frequencies of highly activated regulatory T cells skewed to a T helper 1-like phenotype with reduced suppressive capacity in dengue patients.
Sann S, Heng B, Vo HTM, Arroyo Hornero R, Lay S, Sorn S, Ken S, Ou TP, Laurent D, Yay C, Ly S, Dussart P, Duong V, Sakuntabhai A, Kleinewietfeld M, Cantaert T. Sann S, et al. mBio. 2024 Jun 12;15(6):e0006324. doi: 10.1128/mbio.00063-24. Epub 2024 May 16. mBio. 2024. PMID: 38752787 Free PMC article. - Targeted Demethylation of FOXP3-TSDR Enhances the Suppressive Capacity of STAT6-deficient Inducible T Regulatory Cells.
Arroyo-Olarte RD, Flores-Castelán JC, Armas-López L, Escobedo G, Terrazas LI, Ávila-Moreno F, Leon-Cabrera S. Arroyo-Olarte RD, et al. Inflammation. 2024 May 3. doi: 10.1007/s10753-024-02031-4. Online ahead of print. Inflammation. 2024. PMID: 38700792
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases