Focal infection and transformation in situ of thymus cell subclasses by a thymotropic murine leukemia virus - PubMed (original) (raw)
. 1975 Dec;35(12):3585-95.
- PMID: 172227
Focal infection and transformation in situ of thymus cell subclasses by a thymotropic murine leukemia virus
A Declève et al. Cancer Res. 1975 Dec.
Abstract
Studies on the maturational lineages of thymic lymphocytes have revealed several subclasses which are distinguishable on the basis of cell size, topographic distribution within the thymus, DNA synthetic and mitotic activity, migratory behavior, and other properties. Strain C57BL/Ka mice were inoculated with radiation leukemia virus at different concentrations, and tissues were removed at defined intervals. Sequential sections were analyzed for virus-specific cytoplasmic antigen expression, for morphological evidence of neoplastic transformation, and for alkaline phosphatase activity. The first detectable sign of MuLV infection was the focal appearance of cytoplasmic viral antigens in cells of the outer thymic cortex, followed by coalescence of such foci and, several weeks later, by the appearance of morphologically transformed and alkaline phosphatase-positive cells, again often focally distributed in the outer thymic cortex. These observations strongly suggest that the large, mitotically active cells of the outer thymic cortex are the principal source of target cells for both productive infection and subsequent lymphoma induction by the virus.
Similar articles
- In vivo antigenic modification of tumor cells. III. Metastatic thymic lymphoma specifically infected by thymotropic retrovirus.
Iglehart JD, Weinhold KJ, Huper G, Thiel K, Bolognesi DP. Iglehart JD, et al. J Natl Cancer Inst. 1981 Jul;67(1):123-30. J Natl Cancer Inst. 1981. PMID: 6265678 - Leukemogenesis in vitro induced by thymus epithelial reticulum cells transmitting murine leukemia viruses.
Haas M, Sher T, Smolinsky S. Haas M, et al. Cancer Res. 1977 Jun;37(6):1800-7. Cancer Res. 1977. PMID: 192463 - Detection of infectious centers in C57BL/Ka lymphoid cell populations infected in vitro by the radiation leukemia virus.
Boniver J, Declève A, Finn OJ, Honsik C, Lieberman M, Kaplan HS. Boniver J, et al. Cancer Res. 1980 Mar;40(3):544-9. Cancer Res. 1980. PMID: 6258781 - Virus-specific T cell response prevents lymphoma development in mice infected by intrathymic inoculation of Moloney leukaemia virus (M-MuLV).
Zanovello P, Collavo D, Ronchese F, De Rossi A, Biasi G, Chieco-Bianchi L. Zanovello P, et al. Immunology. 1984 Jan;51(1):9-16. Immunology. 1984. PMID: 6228521 Free PMC article.
Cited by
- Stages in development of mink cell focus-inducing (MCF) virus-accelerated leukemia in AKR mice.
O'Donnell PV, Woller R, Chu A. O'Donnell PV, et al. J Exp Med. 1984 Sep 1;160(3):914-34. doi: 10.1084/jem.160.3.914. J Exp Med. 1984. PMID: 6236277 Free PMC article. - Abrogation of radiation leukemia virus-induced lymphomagenesis by antisera to thymotropic but not to ecotropic or dual-tropic viruses.
Haas M, Jongstra J. Haas M, et al. J Virol. 1980 Nov;36(2):606-10. doi: 10.1128/JVI.36.2.606-610.1980. J Virol. 1980. PMID: 6253681 Free PMC article. - Leukemogenic activity of thymotropic, ecotropic, and xenotropic radiation leukemia virus isolates.
Haas M. Haas M. J Virol. 1978 Mar;25(3):705-9. doi: 10.1128/JVI.25.3.705-709.1978. J Virol. 1978. PMID: 205667 Free PMC article. - Radiation leukemia in C57BL/6 mice. II. Lack of ecotropic virus expression in the majority of lymphomas.
Ihle JN, Joseph DR, Pazmino NH. Ihle JN, et al. J Exp Med. 1976 Dec 1;144(6):1406-23. doi: 10.1084/jem.144.6.1406. J Exp Med. 1976. PMID: 63529 Free PMC article. - Specificity of cell surface virus receptors on radiation leukemia virus and radiation-induced thymic lymphomas.
McGrath MS, Decléve A, Lieberman M, Kaplan HS, Weissman IL. McGrath MS, et al. J Virol. 1978 Dec;28(3):819-27. doi: 10.1128/JVI.28.3.819-827.1978. J Virol. 1978. PMID: 215782 Free PMC article.