Axial patterning in cephalochordates and the evolution of the organizer - PubMed (original) (raw)
. 2007 Feb 8;445(7128):613-7.
doi: 10.1038/nature05472. Epub 2007 Jan 21.
Affiliations
- PMID: 17237766
- DOI: 10.1038/nature05472
Free article
Axial patterning in cephalochordates and the evolution of the organizer
Jr-Kai Yu et al. Nature. 2007.
Free article
Abstract
The organizer of the vertebrate gastrula is an important signalling centre that induces and patterns dorsal axial structures. Although a topic of long-standing interest, the evolutionary origin of the organizer remains unclear. Here we show that the gastrula of the cephalochordate amphioxus expresses dorsal/ventral (D/V) patterning genes (for example, bone morphogenetic proteins (BMPs), Nodal and their antagonists) in patterns reminiscent of those of their vertebrate orthlogues, and that amphioxus embryos, like those of vertebrates, are ventralized by exogenous BMP protein. In addition, Wnt-antagonists (for example, Dkks and sFRP2-like) are expressed anteriorly, whereas Wnt genes themselves are expressed posteriorly, consistent with a role for Wnt signalling in anterior/posterior (A/P) patterning. These results suggest evolutionary conservation of the mechanisms for both D/V and A/P patterning of the early gastrula. In light of recent phylogenetic analyses placing cephalochordates basally in the chordate lineage, we propose that separate signalling centres for patterning the D/V and A/P axes may be an ancestral chordate character.
Similar articles
- Organizing chordates with an organizer.
Garcia-Fernàndez J, D'Aniello S, Escrivà H. Garcia-Fernàndez J, et al. Bioessays. 2007 Jul;29(7):619-24. doi: 10.1002/bies.20596. Bioessays. 2007. PMID: 17563072 Review. - Retinoic acid and Wnt/beta-catenin have complementary roles in anterior/posterior patterning embryos of the basal chordate amphioxus.
Onai T, Lin HC, Schubert M, Koop D, Osborne PW, Alvarez S, Alvarez R, Holland ND, Holland LZ. Onai T, et al. Dev Biol. 2009 Aug 15;332(2):223-33. doi: 10.1016/j.ydbio.2009.05.571. Epub 2009 Jun 1. Dev Biol. 2009. PMID: 19497318 - Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan.
Koop D, Holland ND, Sémon M, Alvarez S, de Lera AR, Laudet V, Holland LZ, Schubert M. Koop D, et al. Dev Biol. 2010 Feb 1;338(1):98-106. doi: 10.1016/j.ydbio.2009.11.016. Epub 2009 Nov 13. Dev Biol. 2010. PMID: 19914237 - Zebrafish admp is required to restrict the size of the organizer and to promote posterior and ventral development.
Lele Z, Nowak M, Hammerschmidt M. Lele Z, et al. Dev Dyn. 2001 Dec;222(4):681-7. doi: 10.1002/dvdy.1222. Dev Dyn. 2001. PMID: 11748836 - Does the isthmic organizer influence D/V patterning of the midbrain?
Alexandre P, Wassef M. Alexandre P, et al. Brain Res Brain Res Rev. 2005 Sep;49(2):127-33. doi: 10.1016/j.brainresrev.2005.04.003. Brain Res Brain Res Rev. 2005. PMID: 15951023 Review.
Cited by
- Cell type and regulatory analysis in amphioxus illuminates evolutionary origin of the vertebrate head.
Markos A, Kubovciak J, Mikula Mrstakova S, Zitova A, Paces J, Machacova S, Kozmik-Jr Z, Kozmik Z, Kozmikova I. Markos A, et al. Nat Commun. 2024 Oct 14;15(1):8859. doi: 10.1038/s41467-024-52938-7. Nat Commun. 2024. PMID: 39402029 Free PMC article. - Combinatorial Wnt signaling landscape during brachiopod anteroposterior patterning.
Vellutini BC, Martín-Durán JM, Børve A, Hejnol A. Vellutini BC, et al. BMC Biol. 2024 Sep 19;22(1):212. doi: 10.1186/s12915-024-01988-w. BMC Biol. 2024. PMID: 39300453 Free PMC article. - Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories.
Dai Y, Zhong Y, Pan R, Yuan L, Fu Y, Chen Y, Du J, Li M, Wang X, Liu H, Shi C, Liu G, Zhu P, Shimeld S, Zhou X, Li G. Dai Y, et al. Nat Ecol Evol. 2024 Sep;8(9):1693-1710. doi: 10.1038/s41559-024-02469-7. Epub 2024 Jul 18. Nat Ecol Evol. 2024. PMID: 39025981 - An amphioxus neurula stage cell atlas supports a complex scenario for the emergence of vertebrate head mesoderm.
Grau-Bové X, Subirana L, Meister L, Soubigou A, Neto A, Elek A, Naranjo S, Fornas O, Gomez-Skarmeta JL, Tena JJ, Irimia M, Bertrand S, Sebé-Pedrós A, Escriva H. Grau-Bové X, et al. Nat Commun. 2024 May 29;15(1):4550. doi: 10.1038/s41467-024-48774-4. Nat Commun. 2024. PMID: 38811547 Free PMC article. - Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.
Mörsdorf D, Knabl P, Genikhovich G. Mörsdorf D, et al. Dev Genes Evol. 2024 Jun;234(1):1-19. doi: 10.1007/s00427-024-00714-4. Epub 2024 Mar 13. Dev Genes Evol. 2024. PMID: 38472535 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources