Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres - PubMed (original) (raw)
doi: 10.1038/ng1952. Epub 2007 Jan 21.
Affiliations
- PMID: 17237781
- DOI: 10.1038/ng1952
Telomere length regulates the epigenetic status of mammalian telomeres and subtelomeres
Roberta Benetti et al. Nat Genet. 2007 Feb.
Abstract
Mammalian telomeres have epigenetic marks of constitutive heterochromatin. Here, we study the impact of telomere length on the maintenance of heterochromatin domains at telomeres. Telomerase-deficient Terc(-/-) mice with short telomeres show decreased trimethylation of histone 3 at Lys9 (H3K9) and histone 4 at Lys20 (H4K20) in telomeric and subtelomeric chromatin as well as decreased CBX3 binding accompanied by increased H3 and H4 acetylation at these regions. Subtelomeric DNA methylation is also decreased in conjunction with telomere shortening in Terc(-/-) mice. In contrast, telomere repeat factors 1 and 2 show normal binding to telomeres independent of telomere length. These results indicate that loss of telomeric repeats leads to a change in the architecture of telomeric and subtelomeric chromatin consisting of loss of heterochromatic features leading to a more 'open' chromatin state. These observations highlight the importance of telomere repeats in the establishment of constitutive heterochromatin at mammalian telomeres and subtelomeres and point to histone modifications as important in counting telomere repeats.
Similar articles
- The epigenetic regulation of mammalian telomeres.
Blasco MA. Blasco MA. Nat Rev Genet. 2007 Apr;8(4):299-309. doi: 10.1038/nrg2047. Nat Rev Genet. 2007. PMID: 17363977 Review. - DNA methyltransferases control telomere length and telomere recombination in mammalian cells.
Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, Blasco MA. Gonzalo S, et al. Nat Cell Biol. 2006 Apr;8(4):416-24. doi: 10.1038/ncb1386. Epub 2006 Mar 26. Nat Cell Biol. 2006. PMID: 16565708 - Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.
Benetti R, Gonzalo S, Jaco I, Schotta G, Klatt P, Jenuwein T, Blasco MA. Benetti R, et al. J Cell Biol. 2007 Sep 10;178(6):925-36. doi: 10.1083/jcb.200703081. J Cell Biol. 2007. PMID: 17846168 Free PMC article. - Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.
García-Cao M, O'Sullivan R, Peters AH, Jenuwein T, Blasco MA. García-Cao M, et al. Nat Genet. 2004 Jan;36(1):94-9. doi: 10.1038/ng1278. Epub 2003 Dec 14. Nat Genet. 2004. PMID: 14702045 - Epigenetic regulation of telomere chromatin integrity in pluripotent embryonic stem cells.
Wong LH. Wong LH. Epigenomics. 2010 Oct;2(5):639-55. doi: 10.2217/epi.10.49. Epigenomics. 2010. PMID: 22122049 Review.
Cited by
- Reprogramming Chromosome Ends by Functional Histone Acetylation.
Meltzer WA, Gupta A, Lin PN, Brown RA, Benyamien-Roufaeil DS, Khatri R, Mahurkar AA, Song Y, Taylor RJ, Zalzman M. Meltzer WA, et al. Int J Mol Sci. 2024 Mar 31;25(7):3898. doi: 10.3390/ijms25073898. Int J Mol Sci. 2024. PMID: 38612707 Free PMC article. - Reduced SIRT1 and SIRT3 and Lower Antioxidant Capacity of Seminal Plasma Is Associated with Shorter Sperm Telomere Length in Oligospermic Men.
Dhillon VS, Shahid M, Deo P, Fenech M. Dhillon VS, et al. Int J Mol Sci. 2024 Jan 5;25(2):718. doi: 10.3390/ijms25020718. Int J Mol Sci. 2024. PMID: 38255792 Free PMC article. - Incomplete reprogramming of DNA replication timing in induced pluripotent stem cells.
Edwards MM, Wang N, Massey DJ, Bhatele S, Egli D, Koren A. Edwards MM, et al. Cell Rep. 2024 Jan 23;43(1):113664. doi: 10.1016/j.celrep.2023.113664. Epub 2024 Jan 8. Cell Rep. 2024. PMID: 38194345 Free PMC article. - Relationship between aging and control of metabolic syndrome with telomere shortening: a cross-sectional study.
Devrajani T, Abid S, Shaikh H, Shaikh I, Devrajani DB, Memon SM, Waryah AM, Ujjan ID, Syed BM. Devrajani T, et al. Sci Rep. 2023 Oct 19;13(1):17878. doi: 10.1038/s41598-023-44715-1. Sci Rep. 2023. PMID: 37857729 Free PMC article. - Histone 4 lysine 20 tri-methylation: a key epigenetic regulator in chromatin structure and disease.
Agredo A, Kasinski AL. Agredo A, et al. Front Genet. 2023 Aug 21;14:1243395. doi: 10.3389/fgene.2023.1243395. eCollection 2023. Front Genet. 2023. PMID: 37671044 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous