Microtubule-organizing centres: a re-evaluation - PubMed (original) (raw)

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doi: 10.1038/nrm2100.

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• PMID: 17245416
• DOI: 10.1038/nrm2100

Review

Microtubule-organizing centres: a re-evaluation

Jens Lüders et al. Nat Rev Mol Cell Biol. 2007 Feb.

Abstract

The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires gamma-tubulin. Here we discuss recent evidence indicating that gamma-tubulin-dependent formation of new microtubules is not restricted to conventional microtubule-organizing centres. These findings suggest that the spatio-temporal control of microtubule nucleation is more complex than previously thought, leading us to a re-evaluation of the concept of the microtubule-organizing center.

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