Genetic Analysis of the Hairy Locus in DROSOPHILA MELANOGASTER - PubMed (original) (raw)

Genetic Analysis of the Hairy Locus in DROSOPHILA MELANOGASTER

P W Ingham et al. Genetics. 1985 Nov.

Abstract

Mutations of the hairy locus in Drosophila may affect both adult chaeta differentiation and embryonic segmentation. In an effort to understand this phenotypic complexity, we have analyzed 30 mutant alleles of the locus. We find that the alleles fall into four groups according to their complementation properties, suggesting a structurally complex locus in which two distinct functions share a common coding region.

PubMed Disclaimer

Similar articles

• The doublesex locus of Drosophila melanogaster and its flanking regions: a cytogenetic analysis.
  Baker BS, Hoff G, Kaufman TC, Wolfner MF, Hazelrigg T. Baker BS, et al. Genetics. 1991 Jan;127(1):125-38. doi: 10.1093/genetics/127.1.125. Genetics. 1991. PMID: 1901816 Free PMC article.
• Drosophila CtBP: a Hairy-interacting protein required for embryonic segmentation and hairy-mediated transcriptional repression.
  Poortinga G, Watanabe M, Parkhurst SM. Poortinga G, et al. EMBO J. 1998 Apr 1;17(7):2067-78. doi: 10.1093/emboj/17.7.2067. EMBO J. 1998. PMID: 9524128 Free PMC article.
• Temperature-sensitive mutations of the notch locus in Drosophila melanogaster.
  Shellenbarger DL, Mohler JD. Shellenbarger DL, et al. Genetics. 1975 Sep;81(1):143-62. doi: 10.1093/genetics/81.1.143. Genetics. 1975. PMID: 812766 Free PMC article.
• Region-specific alleles of the Drosophila segmentation gene hairy.
  Howard K, Ingham P, Rushlow C. Howard K, et al. Genes Dev. 1988 Aug;2(8):1037-46. doi: 10.1101/gad.2.8.1037. Genes Dev. 1988. PMID: 3169547
• Molecular and developmental genetics of the Punch locus, a pterin biosynthesis gene in Drosophila melanogaster.
  O'Donnell JM, McLean JR, Reynolds ER. O'Donnell JM, et al. Dev Genet. 1989;10(3):273-86. doi: 10.1002/dvg.1020100316. Dev Genet. 1989. PMID: 2500290 Review.

Cited by

• Seven genes of the Enhancer of split complex of Drosophila melanogaster encode helix-loop-helix proteins.
  Knust E, Schrons H, Grawe F, Campos-Ortega JA. Knust E, et al. Genetics. 1992 Oct;132(2):505-18. doi: 10.1093/genetics/132.2.505. Genetics. 1992. PMID: 1427040 Free PMC article.
• An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster.
  Dalby B, Pereira AJ, Goldstein LS. Dalby B, et al. Genetics. 1995 Feb;139(2):757-66. doi: 10.1093/genetics/139.2.757. Genetics. 1995. PMID: 7713430 Free PMC article.
• In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.
  Jiménez G, Pinchin SM, Ish-Horowicz D. Jiménez G, et al. EMBO J. 1996 Dec 16;15(24):7088-98. EMBO J. 1996. PMID: 9003784 Free PMC article.
• Origin and evolution of the enhancer of split complex.
  Dearden PK. Dearden PK. BMC Genomics. 2015 Sep 18;16(1):712. doi: 10.1186/s12864-015-1926-1. BMC Genomics. 2015. PMID: 26384649 Free PMC article.
• Studies on the rate and site-specificity of P element transposition.
  Berg CA, Spradling AC. Berg CA, et al. Genetics. 1991 Mar;127(3):515-24. doi: 10.1093/genetics/127.3.515. Genetics. 1991. PMID: 1849859 Free PMC article.

References

1. 1. Cell. 1982 Jul;29(3):995-1004 - PubMed
2. 1. EMBO J. 1984 Mar;3(3):569-73 - PubMed
3. 1. EMBO J. 1982;1(3):307-10 - PubMed
4. 1. Hereditas. 1973;73(1):11-6 - PubMed

LinkOut - more resources

• Full Text Sources

  • Europe PubMed Central
  • PubMed Central
  • Silverchair Information Systems

• Molecular Biology Databases

  • FlyBase