A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A - PubMed (original) (raw)
. 2007 Feb 9;315(5813):820-5.
doi: 10.1126/science.1136244. Epub 2007 Jan 25.
Affiliations
- PMID: 17255476
- DOI: 10.1126/science.1136244
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A
Riki Kawaguchi et al. Science. 2007.
Abstract
Vitamin A has diverse biological functions. It is transported in the blood as a complex with retinol binding protein (RBP), but the molecular mechanism by which vitamin A is absorbed by cells from the vitamin A-RBP complex is not clearly understood. We identified in bovine retinal pigment epithelium cells STRA6, a multitransmembrane domain protein, as a specific membrane receptor for RBP. STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex. It is widely expressed in embryonic development and in adult organ systems. The RBP receptor represents a major physiological mediator of cellular vitamin A uptake.
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