Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis - PubMed (original) (raw)

. 2007 Mar 9;282(10):6917-21.

doi: 10.1074/jbc.C600290200. Epub 2007 Jan 26.

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• PMID: 17259180
• DOI: 10.1074/jbc.C600290200

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Prokineticin 2 is a target gene of proneural basic helix-loop-helix factors for olfactory bulb neurogenesis

Chengkang Zhang et al. J Biol Chem. 2007.

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Abstract

Prokineticin 2, a cysteine-rich secreted protein, regulates diverse biological functions including the neurogenesis of olfactory bulb. Here we show that the PK2 gene is a functional target gene of proneural basic helix-loop-helix (bHLH) factors. Neurogenin 1 and MASH1 activate PK2 transcription by binding to E-box motifs on the PK2 promoter with the same set of E-boxes critical for another pair of bHLH factors, CLOCK and BMAL1, in the regulation of circadian clock. Our results establish PK2 as a common functional target gene for different bHLH transcriptional factors in mediating their respective functions.

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