Noninvasive assessment of plaque characteristics with multislice computed tomography coronary angiography in symptomatic diabetic patients - PubMed (original) (raw)
doi: 10.2337/dc06-2104. Epub 2007 Jan 26.
Affiliations
- PMID: 17259478
- DOI: 10.2337/dc06-2104
Noninvasive assessment of plaque characteristics with multislice computed tomography coronary angiography in symptomatic diabetic patients
Gabija Pundziute et al. Diabetes Care. 2007 May.
Abstract
Objective: Cardiovascular events are high in patients with type 2 diabetes, whereas their risk stratification is more difficult. The higher risk may be related to differences in coronary plaque burden and composition. The purpose of this study was to evaluate whether differences in the extent and composition of coronary plaques in patients with and without diabetes can be observed using multislice computed tomography (MSCT).
Research design and methods: MSCT was performed in 215 patients (86 [40%] with type 2 diabetes). The number of diseased coronary segments was determined per patient; each diseased segment was classified as showing obstructive (> or = 50% luminal narrowing) disease or not. In addition, plaque type (noncalcified, mixed, and calcified) was determined. Plaque characteristics were compared in patients with and without diabetes. Regression analysis was performed to assess the correlation between plaque characteristics and diabetes.
Results: Patients with diabetes showed significantly more diseased coronary segments than nondiabetic patients (4.9 +/- 3.5 vs. 3.9 +/- 3.2, P = 0.03) with more nonobstructive (3.7 +/- 3.0 vs. 2.7 +/- 2.4, P = 0.008) plaques. Relatively more noncalcified (28 vs. 19%) and calcified (49 vs. 43%) and less mixed (23 vs. 38%) plaques were observed in patients with diabetes (P < 0.0001). Diabetes correlated with the number of diseased segments and nonobstructive, noncalcified, and calcified plaques.
Conclusions: Differences in coronary plaque characteristics on MSCT were observed between patients with and without diabetes. Diabetes was associated with higher coronary plaque burden. More noncalcified and calcified plaques and less mixed plaques were observed in diabetic patients. Thus, MSCT may be used to identify differences in coronary plaque burden, which may be useful for risk stratification.
Similar articles
- Prevalence of coronary artery disease and plaque morphology assessed by multi-slice computed tomography coronary angiography and calcium scoring in asymptomatic patients with type 2 diabetes.
Scholte AJ, Schuijf JD, Kharagjitsingh AV, Jukema JW, Pundziute G, van der Wall EE, Bax JJ. Scholte AJ, et al. Heart. 2008 Mar;94(3):290-5. doi: 10.1136/hrt.2007.121921. Epub 2007 Jul 23. Heart. 2008. PMID: 17646190 - Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis.
Pundziute G, Schuijf JD, Jukema JW, Decramer I, Sarno G, Vanhoenacker PK, Reiber JH, Schalij MJ, Wijns W, Bax JJ. Pundziute G, et al. JACC Cardiovasc Interv. 2008 Apr;1(2):176-82. doi: 10.1016/j.jcin.2008.01.007. JACC Cardiovasc Interv. 2008. PMID: 19463297 - Noninvasive assessment of the prevalence and characteristics of coronary atherosclerotic plaques by multidetector computed tomography in asymptomatic type 2 diabetic patients at high risk of significant coronary artery disease: a preliminary study.
Loffroy R, Bernard S, Sérusclat A, Boussel L, Bonnefoy E, D'Athis P, Moulin P, Revel D, Douek P. Loffroy R, et al. Arch Cardiovasc Dis. 2009 Aug-Sep;102(8-9):607-15. doi: 10.1016/j.acvd.2009.04.007. Epub 2009 Jun 25. Arch Cardiovasc Dis. 2009. PMID: 19786264 - [Noninvasive computed tomographic coronary angiography as a complement to coronary calcium quantification in symptomatic patients].
Möhlenkamp S, Schmermund A, Gerber TC, Kerkhoff G, Pump H, Budde T, Erbel R. Möhlenkamp S, et al. Herz. 2003 Mar;28(2):106-18. doi: 10.1007/s00059-003-2452-5. Herz. 2003. PMID: 12669224 Review. German. - Coronary plaque imaging with multislice computed tomography: technique and clinical applications.
Cademartiri F, La Grutta L, Palumbo AA, Maffei E, Runza G, Bartolotta TV, Pugliese F, Mollet NR, Midiri M, Krestin GP. Cademartiri F, et al. Eur Radiol. 2006 Nov;16 Suppl 7:M44-53. doi: 10.1007/s10406-006-0195-0. Eur Radiol. 2006. PMID: 18655266 Review.
Cited by
- Aortic and coronary atherosclerosis: a natural association?
van der Wall EE, van der Laarse A. van der Wall EE, et al. Int J Cardiovasc Imaging. 2009 Feb;25(2):219-22. doi: 10.1007/s10554-008-9389-y. Epub 2008 Nov 27. Int J Cardiovasc Imaging. 2009. PMID: 19037749 No abstract available. - Type 2 diabetes is associated with more advanced coronary atherosclerosis on multislice computed tomography and virtual histology intravascular ultrasound.
Pundziute G, Schuijf JD, Jukema JW, van Werkhoven JM, Nucifora G, Decramer I, Sarno G, Vanhoenacker PK, Reiber JH, Wijns W, Bax JJ. Pundziute G, et al. J Nucl Cardiol. 2009 May-Jun;16(3):376-83. doi: 10.1007/s12350-008-9046-9. Epub 2009 May 13. J Nucl Cardiol. 2009. PMID: 19437085 - Global trans-lesional computed tomography-derived fractional flow reserve gradient is associated with clinical outcomes in diabetic patients with non-obstructive coronary artery disease.
Liu Z, Ding Y, Dou G, Wang X, Shan D, He B, Jing J, Li T, Chen Y, Yang J. Liu Z, et al. Cardiovasc Diabetol. 2023 Jul 26;22(1):186. doi: 10.1186/s12933-023-01901-9. Cardiovasc Diabetol. 2023. PMID: 37496009 Free PMC article. - Carotid and cerebrovascular disease in symptomatic patients with type 2 diabetes: assessment of prevalence and plaque morphology by dual-source computed tomography angiography.
He C, Yang ZG, Chu ZG, Dong ZH, Shao H, Deng W, Chen J, Peng LQ, Tang SS, Xiao JH. He C, et al. Cardiovasc Diabetol. 2010 Dec 18;9:91. doi: 10.1186/1475-2840-9-91. Cardiovasc Diabetol. 2010. PMID: 21167061 Free PMC article.