Regulation of T-cell activation by the cytoskeleton - PubMed (original) (raw)
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doi: 10.1038/nri2021.
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- PMID: 17259969
- DOI: 10.1038/nri2021
Review
Regulation of T-cell activation by the cytoskeleton
Daniel D Billadeau et al. Nat Rev Immunol. 2007 Feb.
Abstract
To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
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