Autophagy-dependent viral recognition by plasmacytoid dendritic cells - PubMed (original) (raw)

. 2007 Mar 9;315(5817):1398-401.

doi: 10.1126/science.1136880. Epub 2007 Feb 1.

Affiliations

• PMID: 17272685
• DOI: 10.1126/science.1136880

Autophagy-dependent viral recognition by plasmacytoid dendritic cells

Heung Kyu Lee et al. Science. 2007.

Abstract

Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-alpha by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.

PubMed Disclaimer

Comment in

• Immunology. Eating in to avoid infection.
  Reis e Sousa C. Reis e Sousa C. Science. 2007 Mar 9;315(5817):1376-7. doi: 10.1126/science.1140002. Science. 2007. PMID: 17347432 No abstract available.
• Role of autophagy in innate viral recognition.
  Iwasaki A. Iwasaki A. Autophagy. 2007 Jul-Aug;3(4):354-6. doi: 10.4161/auto.4114. Epub 2007 Jul 7. Autophagy. 2007. PMID: 17404496

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)

• Research Materials

  • National BioResource Project