Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus - PubMed (original) (raw)
doi: 10.1038/nn1847. Epub 2007 Feb 4.
Affiliations
- PMID: 17277773
- DOI: 10.1038/nn1847
Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
Nohjin Kee et al. Nat Neurosci. 2007 Mar.
Abstract
Throughout adulthood, new neurons are continuously added to the dentate gyrus, a hippocampal subregion that is important in spatial learning. Whether these adult-generated granule cells become functionally integrated into memory networks is not known. We used immunohistochemical approaches to visualize the recruitment of new neurons into circuits supporting water maze memory in intact mice. We show that as new granule cells mature, they are increasingly likely to be incorporated into circuits supporting spatial memory. By the time the cells are 4 or more weeks of age, they are more likely than existing granule cells to be recruited into circuits supporting spatial memory. This preferential recruitment supports the idea that new neurons make a unique contribution to memory processing in the dentate gyrus.
Comment in
- Young and excitable: new neurons in memory networks.
Bischofberger J. Bischofberger J. Nat Neurosci. 2007 Mar;10(3):273-5. doi: 10.1038/nn0307-273. Nat Neurosci. 2007. PMID: 17318218 No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases