Reduced physical activity increases intermuscular adipose tissue in healthy young adults - PubMed (original) (raw)
Controlled Clinical Trial
doi: 10.1093/ajcn/85.2.377.
Affiliations
- PMID: 17284732
- DOI: 10.1093/ajcn/85.2.377
Free article
Controlled Clinical Trial
Reduced physical activity increases intermuscular adipose tissue in healthy young adults
Todd M Manini et al. Am J Clin Nutr. 2007 Feb.
Free article
Abstract
Background: Recent findings suggest that higher levels of intermuscular adipose tissue (IMAT) are associated with glucose dysregulation, lower levels of muscle strength, and a heightened risk of disability. Although several studies have described adaptations in muscle after reduced physical activity, the change in IMAT in healthy young adults is unknown.
Objective: The objective was to determine whether reduced lower limb activity alters IMAT in healthy young adults and to assess whether this change affects muscle strength loss.
Design: The subjects (6 men and 12 women aged 19-28 y) underwent a 4-wk control period, which was followed by 4 wk of unilateral lower limb suspension. Volumes of whole muscle, subcutaneous adipose tissue, and IMAT were assessed by using magnetic resonance imaging in the thigh and calf. Muscle strength was assessed during maximal voluntary isometric contractions.
Results: No changes were observed in the control period. Reduced physical activity decreased thigh and calf muscle volumes by 7.4% and 7.9% (P < 0.001), respectively; no significant change in subcutaneous adipose tissue was observed. Additionally, IMAT increased in both regions; the increase was larger in the calf (20%) than in the thigh (14.5%) (P <or= 0.005) and was partially explained by the loss in muscle (R(2) = 26%). The loss in strength was greater in the thigh (20.4%) than in the calf (15%). Strength loss was associated with increases in IMAT (P = 0.039) after adjustment for the loss in muscle, initial strength, initial IMAT, and initial muscle volume.
Conclusions: IMAT accumulates markedly after reduced activity in healthy young adults. Increases in IMAT may contribute to losses in muscle strength associated with reduced physical activity, but the mechanism responsible is yet to be determined.
Similar articles
- Exercise Training to Decrease Ectopic Intermuscular Adipose Tissue in Individuals With Chronic Diseases: A Systematic Review and Meta-Analysis.
Tuñón-Suárez M, Reyes-Ponce A, Godoy-Órdenes R, Quezada N, Flores-Opazo M. Tuñón-Suárez M, et al. Phys Ther. 2021 Oct 1;101(10):pzab162. doi: 10.1093/ptj/pzab162. Phys Ther. 2021. PMID: 34174085 - Effect of dietary restriction and exercise on lower extremity tissue compartments in obese, older women: a pilot study.
Manini TM, Buford TW, Lott DJ, Vandenborne K, Daniels MJ, Knaggs JD, Patel H, Pahor M, Perri MG, Anton SD. Manini TM, et al. J Gerontol A Biol Sci Med Sci. 2014 Jan;69(1):101-8. doi: 10.1093/gerona/gls337. Epub 2013 May 16. J Gerontol A Biol Sci Med Sci. 2014. PMID: 23682155 Free PMC article. Clinical Trial. - Lower physical activity is associated with higher intermuscular adipose tissue in people with type 2 diabetes and peripheral neuropathy.
Tuttle LJ, Sinacore DR, Cade WT, Mueller MJ. Tuttle LJ, et al. Phys Ther. 2011 Jun;91(6):923-30. doi: 10.2522/ptj.20100329. Epub 2011 Apr 7. Phys Ther. 2011. PMID: 21474636 Free PMC article. - The Metabolic Significance of Intermuscular Adipose Tissue: Is IMAT a Friend or a Foe to Metabolic Health?
Sparks LM, Goodpaster BH, Bergman BC. Sparks LM, et al. Diabetes. 2021 Nov;70(11):2457-2467. doi: 10.2337/dbi19-0006. Diabetes. 2021. PMID: 34711670 Review. - Intermuscular Adipose Tissue: A Brief Review of Etiology, Association With Physical Function and Weight Loss in Older Adults.
Waters DL. Waters DL. Ann Geriatr Med Res. 2019 Mar;23(1):3-8. doi: 10.4235/agmr.19.0001. Epub 2019 Mar 31. Ann Geriatr Med Res. 2019. PMID: 32743278 Free PMC article. Review.
Cited by
- Injection of Adipose-Derived Mesenchymal Stem/Stromal Cells Suppresses Muscle Atrophy Markers and Adipogenic Markers in a Rat Fatty Muscle Degeneration Model.
Koung Ngeun S, Shimizu M, Kaneda M. Koung Ngeun S, et al. Curr Issues Mol Biol. 2024 Jul 24;46(8):7877-7894. doi: 10.3390/cimb46080467. Curr Issues Mol Biol. 2024. PMID: 39194684 Free PMC article. - Age-related changes in ultrasound-assessed muscle composition and postural stability.
Mongold SJ, Georgiev C, Naeije G, Vander Ghinst M, Stock MS, Bourguignon M. Mongold SJ, et al. Sci Rep. 2024 Aug 12;14(1):18688. doi: 10.1038/s41598-024-69374-8. Sci Rep. 2024. PMID: 39134635 Free PMC article. - Studying intramuscular fat deposition and muscle regeneration: insights from a comparative analysis of mouse strains, injury models, and sex differences.
Norris AM, Fierman KE, Campbell J, Pitale R, Shahraj M, Kopinke D. Norris AM, et al. Skelet Muscle. 2024 May 29;14(1):12. doi: 10.1186/s13395-024-00344-4. Skelet Muscle. 2024. PMID: 38812056 Free PMC article. - Lower Extremity Muscle Volume in Unilateral and Bilateral Patellofemoral Pain: A Cross-Sectional Exploratory Study Including Superficial and Deep Muscles.
Kim S, Park J, Boling MC, Glaviano NR. Kim S, et al. J Athl Train. 2024 Sep 1;59(9):915-924. doi: 10.4085/1062-6050-0330.23. J Athl Train. 2024. PMID: 38015817 - Statin use and longitudinal changes in quantitative MRI-based biomarkers of thigh muscle quality: data from Osteoarthritis Initiative.
Mohajer B, Moradi K, Guermazi A, Dolatshahi M, Roemer FW, Ibad HA, Parastooei G, Conaghan PG, Zikria BA, Wan M, Cao X, Lima JAC, Demehri S. Mohajer B, et al. Skeletal Radiol. 2024 Apr;53(4):683-695. doi: 10.1007/s00256-023-04473-7. Epub 2023 Oct 16. Skeletal Radiol. 2024. PMID: 37840051
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources