Ratcheting mRNA out of the nucleus - PubMed (original) (raw)

Review

. 2007 Feb 9;25(3):327-30.

doi: 10.1016/j.molcel.2007.01.016.

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Review

Ratcheting mRNA out of the nucleus

Murray Stewart. Mol Cell. 2007.

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Abstract

Export of mature mRNA to the cytoplasm is the culmination of the nuclear portion of eukaryotic gene expression. After transport-competent mature mRNP export complexes are formed in the nucleus, their passage through nuclear pore complexes (NPCs) is facilitated by the Mex67:Mtr2 heterodimer. At the NPC cytoplasmic face, mRNP remodeling prevents its return to the nucleus and so functions as a molecular ratchet imposing directionality on transport. In budding yeast, recent work suggests that the DEAD-box helicase Dbp5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)).

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