Microfluidic bubble logic - PubMed (original) (raw)
. 2007 Feb 9;315(5813):832-5.
doi: 10.1126/science.1136907.
Affiliations
- PMID: 17289994
- DOI: 10.1126/science.1136907
Microfluidic bubble logic
Manu Prakash et al. Science. 2007.
Abstract
We demonstrate universal computation in an all-fluidic two-phase microfluidic system. Nonlinearity is introduced into an otherwise linear, reversible, low-Reynolds number flow via bubble-to-bubble hydrodynamic interactions. A bubble traveling in a channel represents a bit, providing us with the capability to simultaneously transport materials and perform logical control operations. We demonstrate bubble logic AND/OR/NOT gates, a toggle flip-flop, a ripple counter, timing restoration, a ring oscillator, and an electro-bubble modulator. These show the nonlinearity, gain, bistability, synchronization, cascadability, feedback, and programmability required for scalable universal computation. With increasing complexity in large-scale microfluidic processors, bubble logic provides an on-chip process control mechanism integrating chemistry and computation.
Comment in
- Chemistry. Can droplets and bubbles think?
Epstein IR. Epstein IR. Science. 2007 Feb 9;315(5813):775-6. doi: 10.1126/science.1138325. Science. 2007. PMID: 17289966 No abstract available.
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