High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene - PubMed (original) (raw)
High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
Alejandra Bruna et al. Cancer Cell. 2007 Feb.
Free article
Abstract
TGFbeta acts as a tumor suppressor in normal epithelial cells and early-stage tumors and becomes an oncogenic factor in advanced tumors. The molecular mechanisms involved in the malignant function of TGFbeta are not fully elucidated. We demonstrate that high TGFbeta-Smad activity is present in aggressive, highly proliferative gliomas and confers poor prognosis in patients with glioma. We discern the mechanisms and molecular determinants of the TGFbeta oncogenic response with a transcriptomic approach and by analyzing primary cultured patient-derived gliomas and human glioma biopsies. The TGFbeta-Smad pathway promotes proliferation through the induction of PDGF-B in gliomas with an unmethylated PDGF-B gene. The epigenetic regulation of the PDGF-B gene dictates whether TGFbeta acts as an oncogenic factor inducing PDGF-B and proliferation in human glioma.
Similar articles
- The methylation status of the platelet-derived growth factor-B gene promoter and its regulation of cellular proliferation following folate treatment in human glioma cells.
Zhou Y, Jin G, Mi R, Dong C, Zhang J, Liu F. Zhou Y, et al. Brain Res. 2014 Mar 27;1556:57-66. doi: 10.1016/j.brainres.2014.01.045. Epub 2014 Feb 3. Brain Res. 2014. PMID: 24502980 - Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes.
Godard S, Getz G, Delorenzi M, Farmer P, Kobayashi H, Desbaillets I, Nozaki M, Diserens AC, Hamou MF, Dietrich PY, Regli L, Janzer RC, Bucher P, Stupp R, de Tribolet N, Domany E, Hegi ME. Godard S, et al. Cancer Res. 2003 Oct 15;63(20):6613-25. Cancer Res. 2003. PMID: 14583454 - Increased expression of CCAAT/enhancer binding protein beta correlates with prognosis in glioma patients.
Homma J, Yamanaka R, Yajima N, Tsuchiya N, Genkai N, Sano M, Tanaka R. Homma J, et al. Oncol Rep. 2006 Mar;15(3):595-601. Oncol Rep. 2006. PMID: 16465418 - Platelet-derived growth factor in human glioma.
Westermark B, Heldin CH, Nistér M. Westermark B, et al. Glia. 1995 Nov;15(3):257-63. doi: 10.1002/glia.440150307. Glia. 1995. PMID: 8586462 Review. - Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment.
Hoelzinger DB, Demuth T, Berens ME. Hoelzinger DB, et al. J Natl Cancer Inst. 2007 Nov 7;99(21):1583-93. doi: 10.1093/jnci/djm187. Epub 2007 Oct 30. J Natl Cancer Inst. 2007. PMID: 17971532 Review.
Cited by
- TGF-β signaling in liver and gastrointestinal cancers.
Katz LH, Likhter M, Jogunoori W, Belkin M, Ohshiro K, Mishra L. Katz LH, et al. Cancer Lett. 2016 Sep 1;379(2):166-72. doi: 10.1016/j.canlet.2016.03.033. Epub 2016 Mar 30. Cancer Lett. 2016. PMID: 27039259 Free PMC article. Review. - TGF-β signaling and its targeting for glioma treatment.
Han J, Alvarez-Breckenridge CA, Wang QE, Yu J. Han J, et al. Am J Cancer Res. 2015 Feb 15;5(3):945-55. eCollection 2015. Am J Cancer Res. 2015. PMID: 26045979 Free PMC article. Review. - Molecular Mechanisms and Clinical Challenges of Glioma Invasion.
Oishi T, Koizumi S, Kurozumi K. Oishi T, et al. Brain Sci. 2022 Feb 20;12(2):291. doi: 10.3390/brainsci12020291. Brain Sci. 2022. PMID: 35204054 Free PMC article. Review. - Glioblastoma multiforme in patients with human immunodeficiency virus: an integrated review and analysis.
Mendez Valdez MJ, Lu VM, Kim E, Rivas SR, Govindarajan V, Ivan M, Komotar R, Nath A, Heiss JD, Shah AH. Mendez Valdez MJ, et al. J Neurooncol. 2022 Sep;159(3):571-579. doi: 10.1007/s11060-022-04095-4. Epub 2022 Jul 20. J Neurooncol. 2022. PMID: 35857248 Review. - Targeting of endothelial cells in brain tumours.
Duan W, Xia S, Tang M, Lin M, Liu W, Wang Q. Duan W, et al. Clin Transl Med. 2023 Oct;13(10):e1433. doi: 10.1002/ctm2.1433. Clin Transl Med. 2023. PMID: 37830128 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases