Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension - PubMed (original) (raw)

. 2007 Mar 2;315(5816):1243-9.

doi: 10.1126/science.1136281. Epub 2007 Feb 15.

Monica Kam, Ulf Nannmark, Michelle F Anderson, Mathilda Zetterstrom Axell, Carsten Wikkelso, Stig Holtås, Willeke M C van Roon-Mom, Thomas Björk-Eriksson, Claes Nordborg, Jonas Frisén, Michael Dragunow, Richard L M Faull, Peter S Eriksson

Affiliations

Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension

Maurice A Curtis et al. Science. 2007.

Abstract

The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.

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