Debugging how bacteria manipulate the immune response - PubMed (original) (raw)
Review
Debugging how bacteria manipulate the immune response
Philippe J Sansonetti et al. Immunity. 2007 Feb.
Free article
Abstract
Beyond the innate response that is elicited when tissues are infected, bacterial pathogens have evolved strategies to subvert the immune response and "recalibrate" it both qualitatively and quantitatively, thereby achieving a balance consistent with the survival of both the microbe and its infected host, a compromise that is likely the result of a long process of coevolution between pathogens and their hosts. By collaboratively studying the mechanisms employed, microbiologists and immunologists are fostering development of a renewed approach of infectious diseases that is expected to provide useful new concepts and applications for their control. In addition, the molecular strategies developed by bacteria to dampen immune mechanisms result from such strong and prolonged selective pressure for survival that they may point to original mechanisms and targets to conceive novel immunomodulatory, anti-inflammatory, and anti-infectious molecules.
Similar articles
- Bacterial strategies for overcoming host innate and adaptive immune responses.
Hornef MW, Wick MJ, Rhen M, Normark S. Hornef MW, et al. Nat Immunol. 2002 Nov;3(11):1033-40. doi: 10.1038/ni1102-1033. Nat Immunol. 2002. PMID: 12407412 Review. - Chronic bacterial infections: living with unwanted guests.
Young D, Hussell T, Dougan G. Young D, et al. Nat Immunol. 2002 Nov;3(11):1026-32. doi: 10.1038/ni1102-1026. Nat Immunol. 2002. PMID: 12407411 Review. - Anti-immunology: evasion of the host immune system by bacterial and viral pathogens.
Finlay BB, McFadden G. Finlay BB, et al. Cell. 2006 Feb 24;124(4):767-82. doi: 10.1016/j.cell.2006.01.034. Cell. 2006. PMID: 16497587 Review. - [Vaccine development: strategies for coping with the antigenic diversity of bacteria].
Gottschalk M, Laurent-Lewandowski S. Gottschalk M, et al. Rev Sci Tech. 2007 Apr;26(1):91-103. Rev Sci Tech. 2007. PMID: 17633295 Review. French. - Stealth proteins: in silico identification of a novel protein family rendering bacterial pathogens invisible to host immune defense.
Sperisen P, Schmid CD, Bucher P, Zilian O. Sperisen P, et al. PLoS Comput Biol. 2005 Nov;1(6):e63. doi: 10.1371/journal.pcbi.0010063. Epub 2005 Nov 18. PLoS Comput Biol. 2005. PMID: 16299590 Free PMC article.
Cited by
- A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.
DePaolo RW, Kamdar K, Khakpour S, Sugiura Y, Wang W, Jabri B. DePaolo RW, et al. J Exp Med. 2012 Jul 30;209(8):1437-44. doi: 10.1084/jem.20112339. Epub 2012 Jul 9. J Exp Med. 2012. PMID: 22778390 Free PMC article. - Microbe-dendritic cell dialog controls regulatory T-cell fate.
Grainger JR, Hall JA, Bouladoux N, Oldenhove G, Belkaid Y. Grainger JR, et al. Immunol Rev. 2010 Mar;234(1):305-16. doi: 10.1111/j.0105-2896.2009.00880.x. Immunol Rev. 2010. PMID: 20193027 Free PMC article. Review. - Bacteria That Cause Enteric Diseases Stimulate Distinct Humoral Immune Responses.
Amadou Amani S, Lang ML. Amadou Amani S, et al. Front Immunol. 2020 Sep 16;11:565648. doi: 10.3389/fimmu.2020.565648. eCollection 2020. Front Immunol. 2020. PMID: 33042146 Free PMC article. Review. - Intestinal microbiota: shaping local and systemic immune responses.
Molloy MJ, Bouladoux N, Belkaid Y. Molloy MJ, et al. Semin Immunol. 2012 Feb;24(1):58-66. doi: 10.1016/j.smim.2011.11.008. Epub 2011 Dec 16. Semin Immunol. 2012. PMID: 22178452 Free PMC article. Review. - Reproducible community dynamics of the gastrointestinal microbiota following antibiotic perturbation.
Antonopoulos DA, Huse SM, Morrison HG, Schmidt TM, Sogin ML, Young VB. Antonopoulos DA, et al. Infect Immun. 2009 Jun;77(6):2367-75. doi: 10.1128/IAI.01520-08. Epub 2009 Mar 23. Infect Immun. 2009. PMID: 19307217 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical