Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori - PubMed (original) (raw)

Review

Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori

Marguerite Clyne et al. FEMS Microbiol Lett. 2007 Mar.

Abstract

Helicobacter pylori is a Gram-negative microaerophilic organism that colonizes the gastric mucosa of humans. Helicobacter pylori is one of the most common infections in humans and results in the development of gastritis in all infected individuals, although the majority of people are asymptomatic. A subset of infected people develop serious disease including duodenal ulceration and gastric cancer. Helicobacter pylori exhibits many striking characteristics. It lives in the hostile environment of the stomach and displays a very strict host and tissue tropism. Despite a vigorous immune response, infection persists for the lifetime of the host unless eradicated with antimicrobials. Why H. pylori is so pathogenic in some individuals and not in others is unknown but is thought to be due to a variety of host, environmental and bacterial factors. In this review, some of the bacterial factors that mediate colonization of the gastric mucosa and play a role in the pathogenesis of this organism have been considered.

PubMed Disclaimer

Similar articles

• Of microbe and man: determinants of Helicobacter pylori-related diseases.
  van Amsterdam K, van Vliet AH, Kusters JG, van der Ende A. van Amsterdam K, et al. FEMS Microbiol Rev. 2006 Jan;30(1):131-56. doi: 10.1111/j.1574-6976.2005.00006.x. FEMS Microbiol Rev. 2006. PMID: 16438683 Review.
• [UreI: a Helicobacter pylori protein essential for resistance to acidity and for the early steps of murine gastric mucosa infection].
  Bury-Moné S, Skouloubris S, Labigne A, De Reuse H. Bury-Moné S, et al. Gastroenterol Clin Biol. 2001 Jun-Jul;25(6-7):659-63. Gastroenterol Clin Biol. 2001. PMID: 11673732 French.
• Helicobacter pylori and gastric cancer: what can be learned by studying the response of gastric epithelial cells to the infection?
  Mueller A, Falkow S, Amieva MR. Mueller A, et al. Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1859-64. doi: 10.1158/1055-9965.EPI-04-0820. Cancer Epidemiol Biomarkers Prev. 2005. PMID: 16103426 Review.
• [Is the association of Helicobacter pylori with humans a classical example of parasitism?].
  Pérez-Pérez GI. Pérez-Pérez GI. Rev Gastroenterol Mex. 2000 Oct-Dec;65(4 Suppl 2):7-12. Rev Gastroenterol Mex. 2000. PMID: 11464623 Review. Spanish.
• Virulence factors of Helicobacter pylori.
  Newell DG. Newell DG. Scand J Gastroenterol Suppl. 1991;187:31-8. Scand J Gastroenterol Suppl. 1991. PMID: 1775922 Review.

Cited by

• Impact of Helicobacter pylori infection on fluid duodenal microbial community structure and microbial metabolic pathways.
  Maeda T, Zai H, Fukui Y, Kato Y, Kumade E, Watanabe T, Furusyo N, Nakajima H, Arai K, Ishii Y, Tateda K, Urita Y. Maeda T, et al. BMC Microbiol. 2022 Jan 15;22(1):27. doi: 10.1186/s12866-022-02437-w. BMC Microbiol. 2022. PMID: 35033024 Free PMC article.
• Exploring alternative treatments for Helicobacter pylori infection.
  Ayala G, Escobedo-Hinojosa WI, de la Cruz-Herrera CF, Romero I. Ayala G, et al. World J Gastroenterol. 2014 Feb 14;20(6):1450-69. doi: 10.3748/wjg.v20.i6.1450. World J Gastroenterol. 2014. PMID: 24587621 Free PMC article. Review.
• Immunological detection of 34 KDa outer membrane protein as a functional form of OipA in clinical isolates of Helicobacter pylori.
  Landarani Z, Falsafi T, Mahboubi M, Lameh-Rad B. Landarani Z, et al. Iran J Microbiol. 2014 Oct;6(5):324-9. Iran J Microbiol. 2014. PMID: 25848522 Free PMC article.
• In silico prediction of exposure amino acid sequences of outer inflammatory protein A of Helicobacter pylori for surface display on Eschierchia coli.
  Teymournejad O, Mobarez AM, Hassan ZM, Moazzeni SM, Yakhchali B, Eskandari V. Teymournejad O, et al. Indian J Hum Genet. 2012 Jan;18(1):83-6. doi: 10.4103/0971-6866.96659. Indian J Hum Genet. 2012. PMID: 22754227 Free PMC article.
• Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil.
  Assumpção MB, Martins LC, Melo Barbosa HP, Barile KA, de Almeida SS, Assumpção PP, Corvelo TC. Assumpção MB, et al. World J Gastroenterol. 2010 Jun 28;16(24):3033-9. doi: 10.3748/wjg.v16.i24.3033. World J Gastroenterol. 2010. PMID: 20572307 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Silverchair Information Systems

• Medical

  • MedlinePlus Health Information