Deep brain stimulation for chronic pain investigated with magnetoencephalography - PubMed (original) (raw)
Case Reports
Deep brain stimulation for chronic pain investigated with magnetoencephalography
Morten L Kringelbach et al. Neuroreport. 2007.
Abstract
Deep brain stimulation has shown remarkable potential in alleviating otherwise treatment-resistant chronic pain, but little is currently known about the underlying neural mechanisms. Here for the first time, we used noninvasive neuroimaging by magnetoencephalography to map changes in neural activity induced by deep brain stimulation in a patient with severe phantom limb pain. When the stimulator was turned off, the patient reported significant increases in subjective pain. Corresponding significant changes in neural activity were found in a network including the mid-anterior orbitofrontal and subgenual cingulate cortices; these areas are known to be involved in pain relief. Hence, they could potentially serve as future surgical targets to relieve chronic pain.
Similar articles
- Deep brain stimulation for pain relief: a meta-analysis.
Bittar RG, Kar-Purkayastha I, Owen SL, Bear RE, Green A, Wang S, Aziz TZ. Bittar RG, et al. J Clin Neurosci. 2005 Jun;12(5):515-9. doi: 10.1016/j.jocn.2004.10.005. J Clin Neurosci. 2005. PMID: 15993077 Review. - Abnormal thalamocortical dynamics may be altered by deep brain stimulation: using magnetoencephalography to study phantom limb pain.
Ray NJ, Jenkinson N, Kringelbach ML, Hansen PC, Pereira EA, Brittain JS, Holland P, Holliday IE, Owen S, Stein J, Aziz T. Ray NJ, et al. J Clin Neurosci. 2009 Jan;16(1):32-6. doi: 10.1016/j.jocn.2008.03.004. Epub 2008 Nov 18. J Clin Neurosci. 2009. PMID: 19019684 - Dissociable neural activity to self- vs. externally administered thermal hyperalgesia: a parametric fMRI study.
Mohr C, Leyendecker S, Helmchen C. Mohr C, et al. Eur J Neurosci. 2008 Feb;27(3):739-49. doi: 10.1111/j.1460-9568.2008.06036.x. Eur J Neurosci. 2008. PMID: 18279326 - Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder.
Maihöfner C, Sperling W, Kaltenhäuser M, Bleich S, de Zwaan M, Wiltfang J, Thürauf N, Elstner S, Reulbach U, Lewczuk P, Kornhuber J, Ropohl A. Maihöfner C, et al. Brain Res. 2007 Jan 19;1129(1):200-5. doi: 10.1016/j.brainres.2006.10.048. Epub 2006 Dec 6. Brain Res. 2007. PMID: 17156764 - Translational principles of deep brain stimulation.
Kringelbach ML, Jenkinson N, Owen SL, Aziz TZ. Kringelbach ML, et al. Nat Rev Neurosci. 2007 Aug;8(8):623-35. doi: 10.1038/nrn2196. Nat Rev Neurosci. 2007. PMID: 17637800 Review.
Cited by
- Unveiling the phantom: What neuroimaging has taught us about phantom limb pain.
Browne JD, Fraiser R, Cai Y, Leung D, Leung A, Vaninetti M. Browne JD, et al. Brain Behav. 2022 Mar;12(3):e2509. doi: 10.1002/brb3.2509. Epub 2022 Feb 26. Brain Behav. 2022. PMID: 35218308 Free PMC article. Review. - Nonlinear control of networked dynamical systems.
Morrison M, Kutz JN. Morrison M, et al. IEEE Trans Netw Sci Eng. 2021 Jan-Mar;8(1):174-189. doi: 10.1109/tnse.2020.3032117. Epub 2020 Oct 19. IEEE Trans Netw Sci Eng. 2021. PMID: 33997094 Free PMC article. - Increased sensitivity to strong perturbations in a whole-brain model of LSD.
Jobst BM, Atasoy S, Ponce-Alvarez A, Sanjuán A, Roseman L, Kaelen M, Carhart-Harris R, Kringelbach ML, Deco G. Jobst BM, et al. Neuroimage. 2021 Apr 15;230:117809. doi: 10.1016/j.neuroimage.2021.117809. Epub 2021 Jan 29. Neuroimage. 2021. PMID: 33524579 Free PMC article. - Deep brain stimulation of the brainstem.
Elias GJB, Loh A, Gwun D, Pancholi A, Boutet A, Neudorfer C, Germann J, Namasivayam A, Gramer R, Paff M, Lozano AM. Elias GJB, et al. Brain. 2021 Apr 12;144(3):712-723. doi: 10.1093/brain/awaa374. Brain. 2021. PMID: 33313788 Free PMC article. - Turbulent-like Dynamics in the Human Brain.
Deco G, Kringelbach ML. Deco G, et al. Cell Rep. 2020 Dec 8;33(10):108471. doi: 10.1016/j.celrep.2020.108471. Cell Rep. 2020. PMID: 33296654 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources