Sleep onset REM periods in obsessive compulsive disorder - PubMed (original) (raw)
Sleep onset REM periods in obsessive compulsive disorder
Michael Kluge et al. Psychiatry Res. 2007.
Abstract
Sleep studies in patients with obsessive compulsive disorder (OCD) are sparse and results inconsistent. Moreover, in 3 out of 4 published studies up to 50% of patients suffered from secondary major depression. In this study, 10 inpatients with a DSM-IV diagnosis of OCD without comorbid major depression (Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score >15; Hamilton Depression Rating Scale (HAMD)-21 total score <17) and 10 healthy matched controls were included. Polysomnography of patients (7 males, 3 females, 34.5+/-12.7 years, Y-BOCS: 27.8+/-4.6, HAMD-21: 13.3+/-1.9) and controls (7 males, 3 females, 34.4+/-12.8 years) was recorded, following an adaptation night. Sleep variables did not significantly differ in both groups except that stage 4 sleep was reduced in patients. Three of the patients with OCD, however, exhibited sleep onset REM periods (SOREMPs), i.e. rapid-eye-movement (REM) latencies <10 min. Obsessive compulsive symptoms were significantly (P<0.05) more severe in these patients (Y-BOCS: 32+/-2.0) compared to those without SOREMPs (Y-BOCS 26+/-4.2). This is, to our knowledge, the first report of sleep onset REM periods in OCD.
Similar articles
- Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder.
Kluge M, Schüssler P, Weikel J, Dresler M, Zuber V, Querfurt F, Yassouridis A, Steiger A. Kluge M, et al. Psychoneuroendocrinology. 2006 Oct;31(9):1098-104. doi: 10.1016/j.psyneuen.2006.07.002. Epub 2006 Sep 11. Psychoneuroendocrinology. 2006. PMID: 16965859 - Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder.
Kluge M, Schüssler P, Künzel HE, Dresler M, Yassouridis A, Steiger A. Kluge M, et al. J Psychiatr Res. 2007 Dec;41(11):928-33. doi: 10.1016/j.jpsychires.2006.08.005. Epub 2006 Oct 17. J Psychiatr Res. 2007. PMID: 17049559 - Sleep EEG of patients with obsessive-compulsive disorder.
Hohagen F, Lis S, Krieger S, Winkelmann G, Riemann D, Fritsch-Montero R, Rey E, Aldenhoff J, Berger M. Hohagen F, et al. Eur Arch Psychiatry Clin Neurosci. 1994;243(5):273-8. doi: 10.1007/BF02191585. Eur Arch Psychiatry Clin Neurosci. 1994. PMID: 8172942 - Sleep and obsessive-compulsive disorder (OCD).
Paterson JL, Reynolds AC, Ferguson SA, Dawson D. Paterson JL, et al. Sleep Med Rev. 2013 Dec;17(6):465-74. doi: 10.1016/j.smrv.2012.12.002. Epub 2013 Mar 14. Sleep Med Rev. 2013. PMID: 23499210 Review. - Sleep disturbance in anxiety disorders.
Papadimitriou GN, Linkowski P. Papadimitriou GN, et al. Int Rev Psychiatry. 2005 Aug;17(4):229-36. doi: 10.1080/09540260500104524. Int Rev Psychiatry. 2005. PMID: 16194794 Review.
Cited by
- Sleep, Narcolepsy, and Sodium Oxybate.
Mamelak M. Mamelak M. Curr Neuropharmacol. 2022;20(2):272-291. doi: 10.2174/1570159X19666210407151227. Curr Neuropharmacol. 2022. PMID: 33827411 Free PMC article. - The Association between Insomnia and Anxiety Symptoms in a Naturalistic Anxiety Treatment Setting.
Kaczkurkin AN, Tyler J, Turk-Karan E, Belli G, Asnaani A. Kaczkurkin AN, et al. Behav Sleep Med. 2021 Jan-Feb;19(1):110-125. doi: 10.1080/15402002.2020.1714624. Epub 2020 Jan 20. Behav Sleep Med. 2021. PMID: 31955594 Free PMC article. - Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series.
Fornaro M. Fornaro M. Ann Gen Psychiatry. 2011 Feb 28;10(1):5. doi: 10.1186/1744-859X-10-5. Ann Gen Psychiatry. 2011. PMID: 21356085 Free PMC article. - Sleep and its importance in adolescence and in common adolescent somatic and psychiatric conditions.
Brand S, Kirov R. Brand S, et al. Int J Gen Med. 2011;4:425-42. doi: 10.2147/IJGM.S11557. Epub 2011 Jun 7. Int J Gen Med. 2011. PMID: 21731894 Free PMC article. - Sleep disturbances in obsessive-compulsive disorder: influence of depression symptoms and trait anxiety.
Segalàs C, Labad J, Salvat-Pujol N, Real E, Alonso P, Bertolín S, Jiménez-Murcia S, Soriano-Mas C, Monasterio C, Menchón JM, Soria V. Segalàs C, et al. BMC Psychiatry. 2021 Jan 14;21(1):42. doi: 10.1186/s12888-021-03038-z. BMC Psychiatry. 2021. PMID: 33446149 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Medical