PKC delta and NADPH oxidase in AGE-induced neuronal death - PubMed (original) (raw)
. 2007 Apr 18;416(3):261-5.
doi: 10.1016/j.neulet.2007.02.013. Epub 2007 Feb 9.
Affiliations
- PMID: 17317001
- DOI: 10.1016/j.neulet.2007.02.013
PKC delta and NADPH oxidase in AGE-induced neuronal death
Mariapaola Nitti et al. Neurosci Lett. 2007.
Abstract
Advanced glycation end product (AGE) accumulation in brain is believed to contribute to neuronal death in several neurodegenerative diseases. Neurons exposed to AGEs undergo oxidative stress, but the molecular mechanisms able to induce ROS generation and cell death are not yet clear. In this work, we exposed SH-SY5Y neuroblastoma cells to glycated albumin, as a model of AGE-modified protein, and we observed that cells differentiated by retinoic acid died after AGE exposure, through anion superoxide and peroxide generation, while undifferentiated cells resulted resistant. Retinoic acid induced marked increase in p47phox expression and in catalytic activity of PKC delta: the upregulation of a pathway involving NADPH oxidase and PKC delta is likely to be responsible for neuronal susceptibility to AGE. This hypothesis is confirmed by the fact that pre-treatments of differentiated cells with DPI, an inhibitor of NADPH oxidase, or with rottlerin, an inhibitor of PKC delta, were able to prevent AGE-induced neuronal death.
Similar articles
- PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation.
Nitti M, Furfaro AL, Cevasco C, Traverso N, Marinari UM, Pronzato MA, Domenicotti C. Nitti M, et al. Cell Signal. 2010 May;22(5):828-35. doi: 10.1016/j.cellsig.2010.01.007. Epub 2010 Jan 13. Cell Signal. 2010. PMID: 20074641 - Glycated human serum albumin enhances macrophage inflammatory protein-1beta mRNA expression through protein kinase C-delta and NADPH oxidase in macrophage-like differentiated U937 cells.
Higai K, Satake M, Nishioka H, Azuma Y, Matsumoto K. Higai K, et al. Biochim Biophys Acta. 2008 Feb;1780(2):307-14. doi: 10.1016/j.bbagen.2007.11.010. Epub 2007 Dec 3. Biochim Biophys Acta. 2008. PMID: 18155175 - Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells.
Guimarães EL, Empsen C, Geerts A, van Grunsven LA. Guimarães EL, et al. J Hepatol. 2010 Mar;52(3):389-97. doi: 10.1016/j.jhep.2009.12.007. Epub 2009 Dec 24. J Hepatol. 2010. PMID: 20133001 - PKC-delta-dependent activation of oxidative stress in adipocytes of obese and insulin-resistant mice: role for NADPH oxidase.
Talior I, Tennenbaum T, Kuroki T, Eldar-Finkelman H. Talior I, et al. Am J Physiol Endocrinol Metab. 2005 Feb;288(2):E405-11. doi: 10.1152/ajpendo.00378.2004. Epub 2004 Oct 26. Am J Physiol Endocrinol Metab. 2005. PMID: 15507533 - RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage.
Piras S, Furfaro AL, Domenicotti C, Traverso N, Marinari UM, Pronzato MA, Nitti M. Piras S, et al. Oxid Med Cell Longev. 2016;2016:9348651. doi: 10.1155/2016/9348651. Epub 2016 May 25. Oxid Med Cell Longev. 2016. PMID: 27313835 Free PMC article. Review.
Cited by
- Hypoxia-induced oxidative stress in ischemic retinopathy.
Li SY, Fu ZJ, Lo AC. Li SY, et al. Oxid Med Cell Longev. 2012;2012:426769. doi: 10.1155/2012/426769. Epub 2012 Oct 17. Oxid Med Cell Longev. 2012. PMID: 23125893 Free PMC article. Review. - NOX2-Dependent Reactive Oxygen Species Regulate Formyl-Peptide Receptor 1-Mediated TrkA Transactivation in SH-SY5Y Cells.
Castaldo M, Zollo C, Esposito G, Ammendola R, Cattaneo F. Castaldo M, et al. Oxid Med Cell Longev. 2019 Dec 2;2019:2051235. doi: 10.1155/2019/2051235. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 31871542 Free PMC article. - AGEs, RAGE, and diabetic retinopathy.
Zong H, Ward M, Stitt AW. Zong H, et al. Curr Diab Rep. 2011 Aug;11(4):244-52. doi: 10.1007/s11892-011-0198-7. Curr Diab Rep. 2011. PMID: 21590515 Review. - Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice.
Jiang JX, Chen X, Fukada H, Serizawa N, Devaraj S, Török NJ. Jiang JX, et al. Hepatology. 2013 Oct;58(4):1339-48. doi: 10.1002/hep.26491. Epub 2013 Aug 6. Hepatology. 2013. PMID: 23703665 Free PMC article. - Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells.
Piras S, Furfaro AL, Brondolo L, Passalacqua M, Marinari UM, Pronzato MA, Nitti M. Piras S, et al. Sci Rep. 2017 Aug 8;7(1):7568. doi: 10.1038/s41598-017-08095-7. Sci Rep. 2017. PMID: 28790431 Free PMC article.