Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease - PubMed (original) (raw)
Identification of a novel panel of cerebrospinal fluid biomarkers for Alzheimer's disease
A H Simonsen et al. Neurobiol Aging. 2008 Jul.
Abstract
An early and accurate diagnosis of Alzheimer's disease (AD) is required to initiate symptomatic treatment with currently approved drugs and will be of even greater importance if disease modifying compounds in development display a clinical effect. Protein profiles of human cerebrospinal fluid samples from AD patients (n=95) and population-based healthy controls (n=72) were analyzed by SELDI-TOF-MS in order to discover and characterize novel candidate biomarker combinations that differentiate AD patients from normal aging in this explorative study. Thirty candidate biomarkers (ROC AUC>0.7) were discovered that could differentiate patients with AD from healthy controls. Protein sequence determination and positive identification of 15 biomarkers revealed potential associations between the identified markers and AD pathogenesis. A multi-marker combination of five peaks could distinguish AD from healthy control individuals with high sensitivity (97%) and specificity (98%). The panel of five markers was tested on a blinded independent data set of 30 AD samples and 28 controls giving 100% sensitivity and 97% specificity. This novel panel of biomarkers could potentially be used to improve the accuracy of diagnosis of AD.
Similar articles
- A novel panel of cerebrospinal fluid biomarkers for the differential diagnosis of Alzheimer's disease versus normal aging and frontotemporal dementia.
Simonsen AH, McGuire J, Podust VN, Hagnelius NO, Nilsson TK, Kapaki E, Vassilopoulos D, Waldemar G. Simonsen AH, et al. Dement Geriatr Cogn Disord. 2007;24(6):434-40. doi: 10.1159/000110576. Epub 2007 Oct 30. Dement Geriatr Cogn Disord. 2007. PMID: 17971664 - Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease.
Finehout EJ, Franck Z, Choe LH, Relkin N, Lee KH. Finehout EJ, et al. Ann Neurol. 2007 Feb;61(2):120-9. doi: 10.1002/ana.21038. Ann Neurol. 2007. PMID: 17167789 - Novel panel of cerebrospinal fluid biomarkers for the prediction of progression to Alzheimer dementia in patients with mild cognitive impairment.
Simonsen AH, McGuire J, Hansson O, Zetterberg H, Podust VN, Davies HA, Waldemar G, Minthon L, Blennow K. Simonsen AH, et al. Arch Neurol. 2007 Mar;64(3):366-70. doi: 10.1001/archneur.64.3.366. Arch Neurol. 2007. PMID: 17353378 - Biomarkers for Alzheimer's disease.
Sonnen JA, Keene CD, Montine KS, Li G, Peskind ER, Zhang J, Montine TJ. Sonnen JA, et al. Expert Rev Neurother. 2007 Aug;7(8):1021-8. doi: 10.1586/14737175.7.8.1021. Expert Rev Neurother. 2007. PMID: 17678497 Review. - Alzheimer's disease cerebrospinal fluid biomarker discovery: a proteomics approach.
D'Ascenzo M, Relkin NR, Lee KH. D'Ascenzo M, et al. Curr Opin Mol Ther. 2005 Dec;7(6):557-64. Curr Opin Mol Ther. 2005. PMID: 16372405 Review.
Cited by
- Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders.
Pendyala G, Fox HS. Pendyala G, et al. Genome Med. 2010 Mar 30;2(3):22. doi: 10.1186/gm143. Genome Med. 2010. PMID: 20353544 Free PMC article. - Biomarkers of HIV-1 associated dementia: proteomic investigation of sera.
Wiederin J, Rozek W, Duan F, Ciborowski P. Wiederin J, et al. Proteome Sci. 2009 Mar 17;7:8. doi: 10.1186/1477-5956-7-8. Proteome Sci. 2009. PMID: 19292902 Free PMC article. - In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR).
Guldbrandsen A, Vethe H, Farag Y, Oveland E, Garberg H, Berle M, Myhr KM, Opsahl JA, Barsnes H, Berven FS. Guldbrandsen A, et al. Mol Cell Proteomics. 2014 Nov;13(11):3152-63. doi: 10.1074/mcp.M114.038554. Epub 2014 Jul 18. Mol Cell Proteomics. 2014. PMID: 25038066 Free PMC article. - An automated plasma protein fractionation design: high-throughput perspectives for proteomic analysis.
Boccardi C, Rocchiccioli S, Cecchettini A, Mercatanti A, Citti L. Boccardi C, et al. BMC Res Notes. 2012 Nov 1;5:612. doi: 10.1186/1756-0500-5-612. BMC Res Notes. 2012. PMID: 23116412 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical