Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome - PubMed (original) (raw)
doi: 10.1038/nn1860. Epub 2007 Feb 25.
Affiliations
- PMID: 17322876
- DOI: 10.1038/nn1860
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
Fabian Fernandez et al. Nat Neurosci. 2007 Apr.
Abstract
Ts65Dn mice, a model for Down syndrome, have excessive inhibition in the dentate gyrus, a condition that could compromise synaptic plasticity and mnemonic processing. We show that chronic systemic treatment of these mice with GABAA antagonists at non-epileptic doses causes a persistent post-drug recovery of cognition and long-term potentiation. These results suggest that over-inhibition contributes to intellectual disabilities associated with Down syndrome and that GABAA antagonists may be useful therapeutic agents for this disorder.
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