Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations - PubMed (original) (raw)

. 2007 Mar 22;50(6):1241-53.

doi: 10.1021/jm061213n. Epub 2007 Feb 27.

Silvia Simeoni, Sabrina Castellano, Caterina Vicidomini, Antonello Mai, Antonella Caroli, Anna Tramontano, Claudia Bonaccini, Patrick Trojer, Ingo Bauer, Gerald Brosch, Gianluca Sbardella

Affiliations

• PMID: 17323938
• DOI: 10.1021/jm061213n

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations

Rino Ragno et al. J Med Chem. 2007.

Abstract

The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) of the catalytic domain of the PRMT1 fungal homologue RmtA. The good correlation between computational and biological results makes RmtA a reliable tool for screening arginine methyltransferase inhibitors. In addition, the binding mode analyses of tested derivatives reveal the crucial role of two regions, the pocket formed by Ile12, His13, Met16, and Thr49 and the SAM cisteinic binding site subsite. These regions should be taken into account in the design of novel PRMT inhibitors.

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