Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals - PubMed (original) (raw)

. 2007 Apr 1;195(7):960-4.

doi: 10.1086/511988. Epub 2007 Feb 16.

Luca Piacentini, Sergio Lo Caputo, Yasuyoshi Kanari, Giuliana Magri, Daria Trabattoni, Valentina Naddeo, Lucia Lopalco, Alberto Clivio, Eugenio Cesana, Francesca Fasano, Cristina Bergamaschi, Francesco Mazzotta, Masaaki Miyazawa, Mario Clerici

Affiliations

• PMID: 17330785
• DOI: 10.1086/511988

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals

Mara Biasin et al. J Infect Dis. 2007.

Abstract

Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G), a human cytidine deaminase, is a potent inhibitor of HIV replication. To explore a possible role of this protein in modulating in vivo susceptibility to HIV infection, we analyzed APOBEC3G expression in HIV-exposed seronegative individuals, HIV-seropositive patients, and healthy control subjects. The results showed that the expression of APOBEC3G is significantly increased in peripheral blood mononuclear cells (PBMCs)--mainly CD14(+) cells--and in cervical tissues of HIV-exposed seronegative individuals. Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection.

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