Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles - PubMed (original) (raw)
Review
Human tumor-derived vs dendritic cell-derived exosomes have distinct biologic roles and molecular profiles
Eva Wieckowski et al. Immunol Res. 2006.
Abstract
Microvesicles (MV) or exosomes are produced and secreted by tumor and normal cells. The molecular profile and functions of tumor-derived vs dendritic cell (DC)-derived MV are distinct. The former express death ligands and mediate apoptosis of activated T cells. The latter promote CD4+ T cell proliferation and may play a role in regulating T cell responses. Serving as intercellular communication networks, tumor-derived MV contribute to tumor escape, while DC-derived MV drive and regulate immune response.
Similar articles
- Review: cancer immunotherapy by exosome-based vaccines.
Hao S, Moyana T, Xiang J. Hao S, et al. Cancer Biother Radiopharm. 2007 Oct;22(5):692-703. doi: 10.1089/cbr.2007.368-R. Cancer Biother Radiopharm. 2007. PMID: 17979572 Review. - The potential of exosomes in immunotherapy.
Chaput N, Taïeb J, André F, Zitvogel L. Chaput N, et al. Expert Opin Biol Ther. 2005 Jun;5(6):737-47. doi: 10.1517/14712598.5.6.737. Expert Opin Biol Ther. 2005. PMID: 15952905 Review. - Direct exosome stimulation of peripheral human T cells detected by ELISPOT.
Admyre C, Johansson SM, Paulie S, Gabrielsson S. Admyre C, et al. Eur J Immunol. 2006 Jul;36(7):1772-81. doi: 10.1002/eji.200535615. Eur J Immunol. 2006. PMID: 16761310 - Exosomes for the treatment of human malignancies.
Viaud S, Ullrich E, Zitvogel L, Chaput N. Viaud S, et al. Horm Metab Res. 2008 Feb;40(2):82-8. doi: 10.1055/s-2007-1022548. Horm Metab Res. 2008. PMID: 18283625 Review. - Cancer immunotherapy using dendritic cell-derived exosomes.
Amigorena S. Amigorena S. Medicina (B Aires). 2000;60 Suppl 2:51-4. Medicina (B Aires). 2000. PMID: 11188932
Cited by
- Exosomes Secreted from Human Cancer Cell Lines Contain Inhibitors of Apoptosis (IAP).
Valenzuela MM, Ferguson Bennit HR, Gonda A, Diaz Osterman CJ, Hibma A, Khan S, Wall NR. Valenzuela MM, et al. Cancer Microenviron. 2015 Aug;8(2):65-73. doi: 10.1007/s12307-015-0167-9. Epub 2015 May 16. Cancer Microenviron. 2015. PMID: 25982218 Free PMC article. - The potential of tumor-derived exosomes for noninvasive cancer monitoring.
Whiteside TL. Whiteside TL. Expert Rev Mol Diagn. 2015;15(10):1293-310. doi: 10.1586/14737159.2015.1071666. Epub 2015 Aug 2. Expert Rev Mol Diagn. 2015. PMID: 26289602 Free PMC article. Review. - Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes).
Whiteside TL. Whiteside TL. Biochem Soc Trans. 2013 Feb 1;41(1):245-51. doi: 10.1042/BST20120265. Biochem Soc Trans. 2013. PMID: 23356291 Free PMC article. Review. - Localization and upregulation of survivin in cancer health disparities: a clinical perspective.
Khan S, Ferguson Bennit H, Asuncion Valenzuela MM, Turay D, Diaz Osterman CJ, Moyron RB, Esebanmen GE, Ashok A, Wall NR. Khan S, et al. Biologics. 2015 Jul 9;9:57-67. doi: 10.2147/BTT.S83864. eCollection 2015. Biologics. 2015. PMID: 26185415 Free PMC article. Review. - Exosomes derived from cancerous and non-cancerous cells regulate the anti-tumor response in the tumor microenvironment.
Bae S, Brumbaugh J, Bonavida B. Bae S, et al. Genes Cancer. 2018 Mar;9(3-4):87-100. doi: 10.18632/genesandcancer.172. Genes Cancer. 2018. PMID: 30108680 Free PMC article. Review.
References
- Adv Exp Med Biol. 2003;532:215-21 - PubMed
- Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):738-43 - PubMed
- Clin Cancer Res. 2005 Feb 1;11(3):1010-20 - PubMed
- Nat Med. 1998 May;4(5):594-600 - PubMed
- J Biol Chem. 1987 Jul 5;262(19):9412-20 - PubMed
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials