Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors - PubMed (original) (raw)
Multicenter Study
doi: 10.1093/ajcn/85.3.860.
Affiliations
- PMID: 17344510
- DOI: 10.1093/ajcn/85.3.860
Free article
Multicenter Study
Hypovitaminosis D in British adults at age 45 y: nationwide cohort study of dietary and lifestyle predictors
Elina Hyppönen et al. Am J Clin Nutr. 2007 Mar.
Free article
Abstract
Background: Increased awareness of the importance of vitamin D to health has led to concerns about the prevalence of hypovitaminosis D in many parts of the world.
Objectives: We aimed to determine the prevalence of hypovitaminosis D in the white British population and to evaluate the influence of key dietary and lifestyle risk factors.
Design: We measured 25-hydroxyvitamin D [25(OH)D] in 7437 whites from the 1958 British birth cohort when they were 45 y old.
Results: The prevalence of hypovitaminosis D was highest during the winter and spring, when 25(OH)D concentrations <25, <40, and <75 nmol/L were found in 15.5%, 46.6%, and 87.1% of participants, respectively; the proportions were 3.2%, 15.4%, and 60.9%, respectively, during the summer and fall. Men had higher 25(OH)D concentrations, on average, than did women during the summer and fall but not during the winter and spring (P = 0.006, likelihood ratio test for interaction). 25(OH)D concentrations were significantly higher in participants who used vitamin D supplements or oily fish than in those who did not (P < 0.0001 for both) but were not significantly higher in participants who consumed vitamin D-fortified margarine than in those who did not (P = 0.10). 25(OH)D concentrations <40 nmol/L were twice as likely in the obese as in the nonobese and in Scottish participants as in those from other parts of Great Britain (ie, England and Wales) (P < 0.0001 for both).
Conclusion: Prevalence of hypovitaminosis D in the general population was alarmingly high during the winter and spring, which warrants action at a population level rather than at a risk group level.
Comment in
- The urgent need to recommend an intake of vitamin D that is effective.
Vieth R, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, Holick MF, Hollis BW, Lamberg-Allardt C, McGrath JJ, Norman AW, Scragg R, Whiting SJ, Willett WC, Zittermann A. Vieth R, et al. Am J Clin Nutr. 2007 Mar;85(3):649-50. doi: 10.1093/ajcn/85.3.649. Am J Clin Nutr. 2007. PMID: 17344484 No abstract available.
Similar articles
- Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study.
Hill TR, Granic A, Davies K, Collerton J, Martin-Ruiz C, Siervo M, Mathers JC, Adamson AJ, Francis RM, Pearce SH, Razvi S, Kirkwood TBL, Jagger C. Hill TR, et al. Osteoporos Int. 2016 Mar;27(3):1199-1208. doi: 10.1007/s00198-015-3366-9. Epub 2015 Oct 14. Osteoporos Int. 2016. PMID: 26468040 - Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season.
Alemzadeh R, Kichler J, Babar G, Calhoun M. Alemzadeh R, et al. Metabolism. 2008 Feb;57(2):183-91. doi: 10.1016/j.metabol.2007.08.023. Metabolism. 2008. PMID: 18191047 - Vitamin D status and predictors of hypovitaminosis D in Italian children and adolescents: a cross-sectional study.
Vierucci F, Del Pistoia M, Fanos M, Gori M, Carlone G, Erba P, Massimetti G, Federico G, Saggese G. Vierucci F, et al. Eur J Pediatr. 2013 Dec;172(12):1607-17. doi: 10.1007/s00431-013-2119-z. Eur J Pediatr. 2013. PMID: 23959324 - Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B-PROOF study.
Brouwer-Brolsma EM, Vaes AMM, van der Zwaluw NL, van Wijngaarden JP, Swart KMA, Ham AC, van Dijk SC, Enneman AW, Sohl E, van Schoor NM, van der Velde N, Uitterlinden AG, Lips P, Feskens EJM, Dhonukshe-Rutten RAM, de Groot LCPGM. Brouwer-Brolsma EM, et al. J Steroid Biochem Mol Biol. 2016 Nov;164:168-176. doi: 10.1016/j.jsbmb.2015.08.008. Epub 2015 Aug 11. J Steroid Biochem Mol Biol. 2016. PMID: 26275945 Review. - Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age: the HunMen Study.
Bhattoa HP, Nagy E, More C, Kappelmayer J, Balogh A, Kalina E, Antal-Szalmas P. Bhattoa HP, et al. Osteoporos Int. 2013 Jan;24(1):179-86. doi: 10.1007/s00198-012-1920-2. Epub 2012 Mar 16. Osteoporos Int. 2013. PMID: 22422303 Review.
Cited by
- Globally Estimated UVB Exposure Times Required to Maintain Sufficiency in Vitamin D Levels.
Kift RC, Webb AR. Kift RC, et al. Nutrients. 2024 May 15;16(10):1489. doi: 10.3390/nu16101489. Nutrients. 2024. PMID: 38794727 Free PMC article. - The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans?
Mavar M, Sorić T, Bagarić E, Sarić A, Matek Sarić M. Mavar M, et al. Nutrients. 2024 Apr 15;16(8):1176. doi: 10.3390/nu16081176. Nutrients. 2024. PMID: 38674867 Free PMC article. Review. - Serum 25-Hydroxyvitamin D Status and Vitamin D Supplements Use Are Not Associated with Low Back Pain in the Large UK Biobank Cohort.
Sha S, Chen LJ, Brenner H, Schöttker B. Sha S, et al. Nutrients. 2024 Mar 12;16(6):806. doi: 10.3390/nu16060806. Nutrients. 2024. PMID: 38542718 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical