Dopamine: 50 years in perspective - PubMed (original) (raw)
Review
Dopamine: 50 years in perspective
Susan D Iversen et al. Trends Neurosci. 2007 May.
Abstract
The discovery of dopamine as a neurotransmitter in brain by Arvid Carlsson approximately 50 years ago, and the subsequent insight provided by Paul Greengard into the cellular signalling mechanisms triggered by dopamine, gained these researchers the Nobel Prize for Medicine in 2000. Dopamine research has had a greater impact on the development of biological psychiatry and psychopharmacology than work on any other neurotransmitter. Neuropsychological views of the role of dopamine in the CNS have evolved from that of a simple reward signal to a more complex situation in which dopamine encodes the importance or 'salience' of events in the external world. Hypofunctional dopamine states underlie Parkinson's disease and attention deficit hyperactivity disorder, and there is increasing evidence for dopamine hyperactivity in schizophrenia. Some of the medicines that are most widely used in psychiatry, such as L-DOPA, methylphenidate and neuroleptic drugs, act on dopaminergic mechanisms.
Similar articles
- [Nobel prize in physiology of medicine for year 2000 for research of signal transduction in the nervous system].
Gispen WH. Gispen WH. Ned Tijdschr Geneeskd. 2000 Nov 11;144(46):2184-7. Ned Tijdschr Geneeskd. 2000. PMID: 11103253 Dutch. - [Dopaminergic modulation of cerebral activity and cognitive functions].
Jucaite A. Jucaite A. Medicina (Kaunas). 2002;38(4):357-62. Medicina (Kaunas). 2002. PMID: 12474782 Review. Lithuanian. - Dopamine.
Costa KM, Schoenbaum G. Costa KM, et al. Curr Biol. 2022 Aug 8;32(15):R817-R824. doi: 10.1016/j.cub.2022.06.060. Curr Biol. 2022. PMID: 35944478 - Role of dopamine in schizophrenia and Parkinson's disease.
Birtwistle J, Baldwin D. Birtwistle J, et al. Br J Nurs. 1998 Jul 23-Aug 12;7(14):832-4, 836, 838-41. doi: 10.12968/bjon.1998.7.14.5636. Br J Nurs. 1998. PMID: 9849144 Review.
Cited by
- GABAergic circuits underpin valuative processing.
Hayes DJ. Hayes DJ. Front Syst Neurosci. 2015 May 12;9:76. doi: 10.3389/fnsys.2015.00076. eCollection 2015. Front Syst Neurosci. 2015. PMID: 26029062 Free PMC article. No abstract available. - Dopamine D(2) Receptor-Mediated Heterologous Sensitization of AC5 Requires Signalosome Assembly.
Ejendal KF, Dessauer CW, Hébert TE, Watts VJ. Ejendal KF, et al. J Signal Transduct. 2012;2012:210324. doi: 10.1155/2012/210324. Epub 2012 Mar 12. J Signal Transduct. 2012. PMID: 22523680 Free PMC article. - Dual ameliorative effects of Ningdong granule on dopamine in rat models of Tourette's syndrome.
Zhang F, Li A. Zhang F, et al. Sci Rep. 2015 Jan 16;5:7731. doi: 10.1038/srep07731. Sci Rep. 2015. PMID: 25592875 Free PMC article. - Acute dopamine D(1) and D(2) receptor stimulation does not modulate mismatch negativity (MMN) in healthy human subjects.
Leung S, Croft RJ, Baldeweg T, Nathan PJ. Leung S, et al. Psychopharmacology (Berl). 2007 Nov;194(4):443-51. doi: 10.1007/s00213-007-0865-1. Epub 2007 Jul 5. Psychopharmacology (Berl). 2007. PMID: 17611739 Clinical Trial. - DRD1 and DRD2 Receptor Polymorphisms: Genetic Neuromodulation of the Dopaminergic System as a Risk Factor for ASD, ADHD and ASD/ADHD Overlap.
Mariggiò MA, Palumbi R, Vinella A, Laterza R, Petruzzelli MG, Peschechera A, Gabellone A, Gentile O, Vincenti A, Margari L. Mariggiò MA, et al. Front Neurosci. 2021 Sep 29;15:705890. doi: 10.3389/fnins.2021.705890. eCollection 2021. Front Neurosci. 2021. PMID: 34658761 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases