T(H)-17 cells in the circle of immunity and autoimmunity - PubMed (original) (raw)

Review

T(H)-17 cells in the circle of immunity and autoimmunity

Estelle Bettelli et al. Nat Immunol. 2007 Apr.

Abstract

CD4(+) effector T cells have been categorized into two subsets: T helper type 1 (T(H)1) and T(H)2. Another subset of T cells that produce interleukin 17 (IL-17; 'T(H)-17 cells') has been identified that is highly proinflammatory and induces severe autoimmunity. Whereas IL-23 serves to expand previously differentiated T(H)-17 cell populations, IL-6 and transforming growth factor-beta (TGF-beta) induce the differentiation of T(H)-17 cells from naive precursors. These data suggest a dichotomy between CD4(+) regulatory T cells positive for the transcription factor Foxp3 and T(H)-17 cells: TGF-beta induces Foxp3 and generates induced regulatory T cells, whereas IL-6 inhibits TGF-beta-driven Foxp3 expression and together with TGF-beta induces T(H)-17 cells. Emerging data regarding T(H)-17 cells suggest a very important function for this T cell subset in immunity and disease.

PubMed Disclaimer

Similar articles

• Differentiation and functional analysis of human T(H)17 cells.
  Burgler S, Ouaked N, Bassin C, Basinski TM, Mantel PY, Siegmund K, Meyer N, Akdis CA, Schmidt-Weber CB. Burgler S, et al. J Allergy Clin Immunol. 2009 Mar;123(3):588-95, 595.e1-7. doi: 10.1016/j.jaci.2008.12.017. J Allergy Clin Immunol. 2009. PMID: 19178935
• The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation.
  Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Annunziato F, et al. Int Immunol. 2008 Nov;20(11):1361-8. doi: 10.1093/intimm/dxn106. Epub 2008 Sep 26. Int Immunol. 2008. PMID: 18820263 Review.
• Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.
  Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH. Sutton CE, et al. Immunity. 2009 Aug 21;31(2):331-41. doi: 10.1016/j.immuni.2009.08.001. Epub 2009 Aug 13. Immunity. 2009. PMID: 19682929
• A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses.
  Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupé P, Barillot E, Soumelis V. Volpe E, et al. Nat Immunol. 2008 Jun;9(6):650-7. doi: 10.1038/ni.1613. Epub 2008 May 4. Nat Immunol. 2008. PMID: 18454150
• IL-6: regulator of Treg/Th17 balance.
  Kimura A, Kishimoto T. Kimura A, et al. Eur J Immunol. 2010 Jul;40(7):1830-5. doi: 10.1002/eji.201040391. Eur J Immunol. 2010. PMID: 20583029 Review.

Cited by

• [Pathogenesis of psoriasis].
  Schäkel K, Schön MP, Ghoreschi K. Schäkel K, et al. Hautarzt. 2016 Jun;67(6):422-31. doi: 10.1007/s00105-016-3800-8. Hautarzt. 2016. PMID: 27246016 Review. German.
• Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment.
  Shi G, Lovaas JD, Tan C, Vistica BP, Wawrousek EF, Aziz MK, Rigden RC, Caspi RR, Gery I. Shi G, et al. J Immunol. 2012 Aug 1;189(3):1220-7. doi: 10.4049/jimmunol.1103033. Epub 2012 Jun 27. J Immunol. 2012. PMID: 22745380 Free PMC article.
• On guard: coronin proteins in innate and adaptive immunity.
  Pieters J, Müller P, Jayachandran R. Pieters J, et al. Nat Rev Immunol. 2013 Jul;13(7):510-8. doi: 10.1038/nri3465. Epub 2013 Jun 14. Nat Rev Immunol. 2013. PMID: 23765056 Review.
• IL-17A mediates inflammatory and tissue remodelling events in early human tendinopathy.
  Millar NL, Akbar M, Campbell AL, Reilly JH, Kerr SC, McLean M, Frleta-Gilchrist M, Fazzi UG, Leach WJ, Rooney BP, Crowe LA, Murrell GA, McInnes IB. Millar NL, et al. Sci Rep. 2016 Jun 6;6:27149. doi: 10.1038/srep27149. Sci Rep. 2016. PMID: 27263531 Free PMC article.
• Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis.
  Wu HP, Chung K, Lin CY, Jiang BY, Chuang DY, Liu YC. Wu HP, et al. Inflamm Res. 2013 Aug;62(8):751-63. doi: 10.1007/s00011-013-0630-3. Epub 2013 May 14. Inflamm Res. 2013. PMID: 23670410 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Research Materials

  • NCI CPTC Antibody Characterization Program