The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci - PubMed (original) (raw)
Review
The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci
Gordon Churchward. Mol Microbiol. 2007 Apr.
Free article
Abstract
The group A streptococcus (GAS) causes a variety of human diseases, including toxic shock syndrome and necrotizing fasciitis, which are both associated with significant mortality. Even the superficial self-limiting diseases caused by GAS, such as pharyngitis, impose a significant economic burden on society. GAS can cause a wide spectrum of diseases because it elaborates virulence factors that enable it to spread and survive in different environmental niches within the human host. The production of many of these virulence factors is directly controlled by the activity of the CovR/S two-component regulatory system. CovS acts in one direction as a kinase primarily to activate the response regulator CovR and repress the expression of major virulence factors and in the other direction as a phosphatase to permit gene expression in response to environmental changes that mimic conditions found during human infection. This Janus-like behaviour of the CovR/S system is recapitulated in the binding of CovR to the promoters that it directly regulates. Interactions between different faces of the CovR DNA binding domain appear to depend upon DNA sequence, leading to the potential for differential regulation of virulence gene expression.
Similar articles
- CovS inactivates CovR and is required for growth under conditions of general stress in Streptococcus pyogenes.
Dalton TL, Scott JR. Dalton TL, et al. J Bacteriol. 2004 Jun;186(12):3928-37. doi: 10.1128/JB.186.12.3928-3937.2004. J Bacteriol. 2004. PMID: 15175307 Free PMC article. - RocA Regulates Phosphatase Activity of Virulence Sensor CovS of Group A Streptococcus in Growth Phase- and pH-Dependent Manners.
Chiang-Ni C, Chiou HJ, Tseng HC, Hsu CY, Chiu CH. Chiang-Ni C, et al. mSphere. 2020 May 20;5(3):e00361-20. doi: 10.1128/mSphere.00361-20. mSphere. 2020. PMID: 32434842 Free PMC article. - Hyperphosphorylation of the Group A Streptococcal Control of Virulence Regulator Increases Promoter Occupancy Specifically at Virulence Factor-Encoding Genes.
Horstmann N, Tran CN, Flores AR, Shelburne SA. Horstmann N, et al. J Bacteriol. 2023 Jun 27;205(6):e0011823. doi: 10.1128/jb.00118-23. Epub 2023 Jun 8. J Bacteriol. 2023. PMID: 37289078 Free PMC article. - Cellular interactions of covR/S mutant group A Streptococci.
Langshaw EL, Pandey M, Good MF. Langshaw EL, et al. Microbes Infect. 2018 Oct-Nov;20(9-10):531-535. doi: 10.1016/j.micinf.2017.12.009. Epub 2017 Dec 26. Microbes Infect. 2018. PMID: 29287985 Review. - Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions.
Kreikemeyer B, McIver KS, Podbielski A. Kreikemeyer B, et al. Trends Microbiol. 2003 May;11(5):224-32. doi: 10.1016/s0966-842x(03)00098-2. Trends Microbiol. 2003. PMID: 12781526 Review.
Cited by
- Dynamic imaging of host-pathogen interactions in vivo.
Coombes JL, Robey EA. Coombes JL, et al. Nat Rev Immunol. 2010 May;10(5):353-64. doi: 10.1038/nri2746. Epub 2010 Apr 16. Nat Rev Immunol. 2010. PMID: 20395980 Review. - Contribution of cryptic epitopes in designing a group A streptococcal vaccine.
Ozberk V, Pandey M, Good MF. Ozberk V, et al. Hum Vaccin Immunother. 2018;14(8):2034-2052. doi: 10.1080/21645515.2018.1462427. Epub 2018 Jun 14. Hum Vaccin Immunother. 2018. PMID: 29873591 Free PMC article. - A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes.
Liang Z, Zhang Y, Agrahari G, Chandrahas V, Glinton K, Donahue DL, Balsara RD, Ploplis VA, Castellino FJ. Liang Z, et al. J Biol Chem. 2013 Mar 1;288(9):6561-73. doi: 10.1074/jbc.M112.442657. Epub 2013 Jan 13. J Biol Chem. 2013. PMID: 23316057 Free PMC article. - RssAB-FlhDC-ShlBA as a major pathogenesis pathway in Serratia marcescens.
Lin CS, Horng JT, Yang CH, Tsai YH, Su LH, Wei CF, Chen CC, Hsieh SC, Lu CC, Lai HC. Lin CS, et al. Infect Immun. 2010 Nov;78(11):4870-81. doi: 10.1128/IAI.00661-10. Epub 2010 Aug 16. Infect Immun. 2010. PMID: 20713626 Free PMC article. - Serotype- and strain- dependent contribution of the sensor kinase CovS of the CovRS two-component system to Streptococcus pyogenes pathogenesis.
Sugareva V, Arlt R, Fiedler T, Riani C, Podbielski A, Kreikemeyer B. Sugareva V, et al. BMC Microbiol. 2010 Feb 1;10:34. doi: 10.1186/1471-2180-10-34. BMC Microbiol. 2010. PMID: 20113532 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources