Siglecs and their roles in the immune system - PubMed (original) (raw)
Review
doi: 10.1038/nri2056.
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- PMID: 17380156
- DOI: 10.1038/nri2056
Review
Siglecs and their roles in the immune system
Paul R Crocker et al. Nat Rev Immunol. 2007 Apr.
Abstract
Cell surfaces in the immune system are richly equipped with a complex mixture of glycans, which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of sialic-acid-binding immunoglobulin-like lectins that are thought to promote cell-cell interactions and regulate the functions of cells in the innate and adaptive immune systems through glycan recognition. In this Review, we describe recent studies on signalling mechanisms and discuss the potential role of Siglecs in triggering endocytosis and in pathogen recognition. Finally, we discuss the postulated functions of the recently discovered CD33-related Siglecs and consider the factors that seem to be driving their rapid evolution.
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