Anaerobic gene expression in Staphylococcus aureus - PubMed (original) (raw)

FIG. 1.

Assignment of genes and proteins in S. aureus COL to biochemical pathways and transport processes. (A) Glycolysis and citric acid cycle. (B) Nitrate respiration. (C) Fermentation. (D) Transport processes. Transcriptomic (T) and proteomic (P) data for the respective enzymes are presented (induction ratios as logarithm to the base 2 are shown). Green boxes denote time points when the respective transcript or protein was significantly upregulated, red boxes denote time points when the respective transcript or protein was significantly downregulated under anaerobic conditions, and yellow boxes indicate that there were no significant changes. For some enzymes of the pathways, no results could be shown since either the proteins could not be identified on the gels or no microarray results were available. AckA, acetate kinase; AcnA, aconitate hydratase; Acs, acetyl-CoA synthetase; AtpB, ATP synthase F0, subunit A; AtpD, ATP synthase F0, subunit D; AtpF, ATP synthase F0, subunit F; BudA1, α-acetolactate decarboxylase; BudB, acetolactate synthase; Eno, enolase; Fba, fructose-bisphosphate aldolase; FumC, fumarate hydratase; GalU, UTP-glucose-1-phosphate uridylyltransferase; GapA1, glyceraldehyde-3-phosphate dehydrogenase; GlcK, glucokinase; GltA, citrate synthase; Icd, isocitrate dehydrogenase; Ldh1, lactate dehydrogenase; Ldh2, lactate dehydrogenase; Mqo1, malate:quinone oxidoreductase; Mqo2, malate:quinine oxidoreductase; NarG, respiratory nitrate reductase, alpha subunit; NarH, respiratory nitrate reductase, beta subunit; NarI, respiratory nitrate reductase, gamma subunit; NarJ, respiratory nitrate reductase, delta subunit; NirB, nitrite reductase, subunit; NirD, nitrite reductase, small subunit; NirR, transcriptional regulator; PckA, phosphoenolpyruvate carboxykinase; PdhA, pyruvate dehydrogenase complex E1 component, alpha subunit; PdhB, pyruvate dehydrogenase component E1; PdhC, pyruvate dehydrogenase component E2; PdhD, pyruvate dehydrogenase component E3; PfkA, phosphofructokinase; PflA, pyuvate formate lyase-activating enzyme; PflB, pyruvate formate lyase; Pgi, glucose-6-phosphate isomerase; Pgk, phosphoglycerate kinase; Pgm, phosphoglycerate mutase; Pta, phosphate acetyltransferase; Pyc, pyruvate carboxylase; Pyk, pyruvate kinase; SACOL0111, acetoin reductase; SACOL0113, NAD-dependent epimerase/dehydratase family protein; SACOL0135, alcohol dehydrogenase; SACOL0301, formate/nitrite transporter protein; SACOL0660, alcohol dehydrogenase; SACOL1749, malic enzyme, flavoprotein chain; SACOL2146, manitol specific IIBC component; SACOL2148, manitol specific IIA component; SACOL2363, L-lactate permease; SACOL2386, nitrite extrusion protein; SdhA, succinate dehydrogenase; SdhB, succinate dehydrogenase, iron-sulfur protein; SdhC, succinate dehydrogenase, cytochrome b558 subunit; SucA, 2-oxoglutarate dehydrogenase component E1; SucB, 2-oxoglutarate dehydrogenase component E2; SucC, succinyl-CoA synthetase, beta subunit; SucD, succinyl-CoA synthetase, alpha subunit; TpiA, triosephosphate isomerase.