Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation - PubMed (original) (raw)

Review

doi: 10.1038/nrc2111.

Affiliations

Review

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

Masao Matsuoka et al. Nat Rev Cancer. 2007 Apr.

Abstract

It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources