Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes: the Nurses' Health Study - PubMed (original) (raw)
doi: 10.2337/dc06-2363. Epub 2007 Mar 27.
Affiliations
- PMID: 17389335
- DOI: 10.2337/dc06-2363
Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes: the Nurses' Health Study
Mohsen Janghorbani et al. Diabetes Care. 2007 Jul.
Abstract
Objective: The aim of this study was to examine the relationship between type 1 and type 2 diabetes and risk of stroke subtypes in women.
Research design and methods: We followed 116,316 women aged 30-55 years in 1976 through 2002 for incidence of stroke. At baseline and through biennial follow-up, women were asked about their history and treatment of diabetes and other potential risk factors for stroke.
Results: During 2.87 million person-years of follow-up, 3,463 incident strokes occurred. In multivariate analyses, the incidence of total stroke was fourfold higher in women with type 1 diabetes (relative risk [RR] 4.7 [95% CI 3.3-6.6]) and twofold higher among women with type 2 diabetes (1.8 [1.7-2.0]) than for nondiabetic women. The multivariate RR of ischemic stroke was increased sixfold (6.3 [4.0-9.8]) in type 1 diabetes and twofold (2.3 [2.0-2.6]) in type 2 diabetes. Risks for large-artery infarction and lacunar stroke were similar. Type 1 diabetes was also significantly associated with the risk of hemorrhagic stroke (3.8 [1.2-11.8]), but type 2 diabetes was not (1.0 [0.7-1.4]).
Conclusions: Both type 1 and type 2 diabetes are associated with substantially increased risks of total and most subtypes of stroke.
Comment in
- Prospective study of type 1 and type 2 diabetes and risk of stroke subtypes: the Nurses' Health Study: response to Janghorbani et al.
Tuttolomondo A, Pinto A, Di Raimondo D, Licata G. Tuttolomondo A, et al. Diabetes Care. 2007 Nov;30(11):e114; author reply e115. doi: 10.2337/dc07-1333. Diabetes Care. 2007. PMID: 17965298 No abstract available.
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