Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1 - PubMed (original) (raw)

Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1

J M Rodríguez-Martínez et al. Antimicrob Agents Chemother. 2007 Jun.

Abstract

The influence of qnrA1 on the development of quinolone resistance in Enterobacteriaceae was evaluated by using the mutant prevention concentration parameter. The expression of qnrA1 considerably increased the mutant prevention concentration compared to strains without this gene. In the presence of qnrA1, mutations in gyrA and parC genes were easily selected to produce high levels of quinolone resistance.

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Figures

FIG. 1.

MPC assays. MIC and MPC values are indicated on figures by arrows. CIP, ciprofloxacin; MXF, moxifloxacin.

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Mutant prevention concentrations of fluoroquinolones for Enterobacteriaceae expressing the plasmid-carried quinolone resistance determinant qnrA1 - PubMed (original) (raw)