Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer - PubMed (original) (raw)
Comparative Study
doi: 10.1038/ng2006. Epub 2007 Apr 8.
Phillip R Stahl, Christian Ruiz, Olaf Hellwinkel, Zeenath Jehan, Marc Wendland, Annette Lebeau, Luigi Terracciano, Khawla Al-Kuraya, Fritz Jänicke, Guido Sauter, Ronald Simon
Affiliations
- PMID: 17417639
- DOI: 10.1038/ng2006
Comparative Study
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Frederik Holst et al. Nat Genet. 2007 May.
Abstract
Using an Affymetrix 10K SNP array to screen for gene copy number changes in breast cancer, we detected a single-gene amplification of the ESR1 gene, which encodes estrogen receptor alpha, at 6q25. A subsequent tissue microarray analysis of more than 2,000 clinical breast cancer samples showed ESR1 amplification in 20.6% of breast cancers. Ninety-nine percent of tumors with ESR1 amplification showed estrogen receptor protein overexpression, compared with 66.6% cancers without ESR1 amplification (P < 0.0001). In 175 women who had received adjuvant tamoxifen monotherapy, survival was significantly longer for women with cancer with ESR1 amplification than for women with estrogen receptor-expressing cancers without ESR1 amplification (P = 0.023). Notably, we also found ESR1 amplification in benign and precancerous breast diseases, suggesting that ESR1 amplification may be a common mechanism in proliferative breast disease and a very early genetic alteration in a large subset of breast cancers.
Comment in
- ESR1 gene amplification in breast cancer: a common phenomenon?
Brown LA, Hoog J, Chin SF, Tao Y, Zayed AA, Chin K, Teschendorff AE, Quackenbush JF, Marioni JC, Leung S, Perou CM, Neilsen TO, Ellis M, Gray JW, Bernard PS, Huntsman DG, Caldas C. Brown LA, et al. Nat Genet. 2008 Jul;40(7):806-7; author reply 810-2. doi: 10.1038/ng0708-806. Nat Genet. 2008. PMID: 18583964 Free PMC article. No abstract available. - ESR1 gene amplification in breast cancer: a common phenomenon?
Horlings HM, Bergamaschi A, Nordgard SH, Kim YH, Han W, Noh DY, Salari K, Joosse SA, Reyal F, Lingjaerde OC, Kristensen VN, Børresen-Dale AL, Pollack J, van de Vijver MJ. Horlings HM, et al. Nat Genet. 2008 Jul;40(7):807-8; author reply 810-2. doi: 10.1038/ng0708-807. Nat Genet. 2008. PMID: 18583965 No abstract available. - ESR1 gene amplification in breast cancer: a common phenomenon?
Reis-Filho JS, Drury S, Lambros MB, Marchio C, Johnson N, Natrajan R, Salter J, Levey P, Fletcher O, Peto J, Ashworth A, Dowsett M. Reis-Filho JS, et al. Nat Genet. 2008 Jul;40(7):809-10; author reply 810-2. doi: 10.1038/ng0708-809b. Nat Genet. 2008. PMID: 18583966 No abstract available. - ESR1 gene amplification in breast cancer: a common phenomenon?
Vincent-Salomon A, Raynal V, Lucchesi C, Gruel N, Delattre O. Vincent-Salomon A, et al. Nat Genet. 2008 Jul;40(7):809; author reply 810-2. doi: 10.1038/ng0708-809a. Nat Genet. 2008. PMID: 18583967 No abstract available.
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