Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells - PubMed (original) (raw)
doi: 10.1038/nm1572. Epub 2007 Apr 8.
Affiliations
- PMID: 17417648
- DOI: 10.1038/nm1572
Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells
Brian L Bishop et al. Nat Med. 2007 May.
Abstract
The superficial bladder epithelium is a powerful barrier to urine and also serves as a regulator of bladder volume, which is achieved by apical exocytosis of specialized fusiform vesicles during distension of the bladder. We report that type 1 fimbriated uropathogenic Escherichia coli (UPEC) circumvents the bladder barrier by harboring in these Rab27b/CD63-positive and cAMP-regulatable fusiform vesicles within bladder epithelial cells (BECs). Incorporation of UPEC into BEC fusiform compartments enabled bacteria to escape elimination during voiding and to re-emerge in the urine as the bladder distended. Notably, treatment of UPEC-infected mice with a drug that increases intracellular cAMP and induces exocytosis of fusiform vesicles reduced the number of intracellular E. coli.
Comment in
- Flushing bacteria out of the bladder.
Eto DS, Mulvey MA. Eto DS, et al. Nat Med. 2007 May;13(5):531-2. doi: 10.1038/nm0507-531. Nat Med. 2007. PMID: 17479092 No abstract available.
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