Bluetongue virus VP4 is an RNA-capping assembly line - PubMed (original) (raw)
doi: 10.1038/nsmb1225. Epub 2007 Apr 8.
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- PMID: 17417654
- DOI: 10.1038/nsmb1225
Bluetongue virus VP4 is an RNA-capping assembly line
Geoff Sutton et al. Nat Struct Mol Biol. 2007 May.
Abstract
Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.
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