A method to the madness of N-glycan complexity? - PubMed (original) (raw)
Comment
. 2007 Apr 6;129(1):27-9.
doi: 10.1016/j.cell.2007.03.022.
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- PMID: 17418781
- DOI: 10.1016/j.cell.2007.03.022
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Comment
A method to the madness of N-glycan complexity?
Pamela Stanley. Cell. 2007.
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Abstract
Cell-surface glycoprotein receptors have varying numbers of N-glycan sites. In this issue of Cell, Lau et al. (2007) report that increasing intracellular UDP-GlcNAc leads to increased branching of N-glycans, increased receptor association with cell-surface galectin-3, and enhanced signaling. They also show that the kinetics of this response differ between growth-promoting receptors, which have 8-16 N-glycans, and those that induce growth arrest, which have very few N-glycans, suggesting that hexosamine flux may regulate the transition from growth to arrest.
Comment on
- Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.
Lau KS, Partridge EA, Grigorian A, Silvescu CI, Reinhold VN, Demetriou M, Dennis JW. Lau KS, et al. Cell. 2007 Apr 6;129(1):123-34. doi: 10.1016/j.cell.2007.01.049. Cell. 2007. PMID: 17418791
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